Femstat_3
Category
Femstat_3 Brand names, Femstat_3 Analogs
Femstat_3 Brand Names Mixture
No information avaliable
Femstat_3 Chemical_Formula
C19H17Cl3N2S
Femstat_3 RX_link
http://www.rxlist.com/cgi/generic2/butoconazole.htm
Femstat_3 fda sheet
Femstat_3 msds (material safety sheet)
Femstat_3 Synthesis Reference
No information avaliable
Femstat_3 Molecular Weight
411.776 g/mol
Femstat_3 Melting Point
Melts at about 159°C with decomposition (nitrate salt)
Femstat_3 H2O Solubility
Nitrate salt: 0.26 mg/ml (practically insoluble)
Femstat_3 State
Solid
Femstat_3 LogP
6.512
Femstat_3 Dosage Forms
Vaginal cream (2%)
Femstat_3 Indication
For the local treatment of vulvovaginal candidiasis (infections caused by Candida)
Femstat_3 Pharmacology
Butoconazole is an imidazole derivative that has fungicidal activity in vitro against Candida spp. and has been demonstrated to be clinically effective against vaginal infections due to Candida albicans. Candida albicans has been identified as the predominant species responsible for vulvovaginal candidasis.
Femstat_3 Absorption
Following vaginal administration of butoconazole nitrate vaginal cream, 2% to 3 women, 1.7% (range 1.3-2.2%) of the dose was absorbed on average.
Femstat_3 Toxicity
Oral, rat: LD50 = >1720 mg/kg.
Femstat_3 Patient Information
Femstat_3 Organisms Affected
Fungi, yeast and protozoans
