5_Fluorodeoxyuridine
Category
5_Fluorodeoxyuridine Brand names, 5_Fluorodeoxyuridine Analogs
5_Fluorodeoxyuridine Brand Names Mixture
No information avaliable
5_Fluorodeoxyuridine Chemical_Formula
C9H11FN2O5
5_Fluorodeoxyuridine RX_link
http://www.rxlist.com/cgi/generic2/floxuridine.htm
5_Fluorodeoxyuridine fda sheet
5_Fluorodeoxyuridine msds (material safety sheet)
5_Fluorodeoxyuridine Synthesis Reference
No information avaliable
5_Fluorodeoxyuridine Molecular Weight
246.193 g/mol
5_Fluorodeoxyuridine Melting Point
150.5 oC
5_Fluorodeoxyuridine H2O Solubility
1.19E+004 mg/L
5_Fluorodeoxyuridine State
Solid
5_Fluorodeoxyuridine LogP
-1.249
5_Fluorodeoxyuridine Dosage Forms
Powder for solution (500mg vial)
5_Fluorodeoxyuridine Indication
For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.
5_Fluorodeoxyuridine Pharmacology
Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.
5_Fluorodeoxyuridine Absorption
No information avaliable
5_Fluorodeoxyuridine Toxicity
Oral, rat LD50: 215 mg/kg. Signs of overdose include nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, and bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis).
5_Fluorodeoxyuridine Patient Information
5_Fluorodeoxyuridine Organisms Affected
Humans and other mammals
