Floxuridin en es it fr

Floxuridin Brand names, Floxuridin Analogs

Floxuridin Brand Names Mixture

  • No information avaliable

Floxuridin Chemical_Formula

C9H11FN2O5

Floxuridin RX_link

http://www.rxlist.com/cgi/generic2/floxuridine.htm

Floxuridin fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=floxuridine%20(intraarterial)

Floxuridin msds (material safety sheet)

Floxuridin MSDS

Floxuridin Synthesis Reference

No information avaliable

Floxuridin Molecular Weight

246.193 g/mol

Floxuridin Melting Point

150.5 oC

Floxuridin H2O Solubility

1.19E+004 mg/L

Floxuridin State

Solid

Floxuridin LogP

-1.249

Floxuridin Dosage Forms

Powder for solution (500mg vial)

Floxuridin Indication

For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.

Floxuridin Pharmacology

Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.

Floxuridin Absorption

No information avaliable

Floxuridin side effects and Toxicity

Oral, rat LD50: 215 mg/kg. Signs of overdose include nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, and bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis).

Floxuridin Patient Information

Floxuridin Organisms Affected

Humans and other mammals