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Fdurd Brand names, Fdurd Analogs

Fdurd Brand Names Mixture

  • No information avaliable

Fdurd Chemical_Formula


Fdurd RX_link


Fdurd fda sheet


Fdurd msds (material safety sheet)

Fdurd MSDS

Fdurd Synthesis Reference

No information avaliable

Fdurd Molecular Weight

246.193 g/mol

Fdurd Melting Point

150.5 oC

Fdurd H2O Solubility

1.19E+004 mg/L

Fdurd State


Fdurd LogP


Fdurd Dosage Forms

Powder for solution (500mg vial)

Fdurd Indication

For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.

Fdurd Pharmacology

Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.

Fdurd Absorption

No information avaliable

Fdurd side effects and Toxicity

Oral, rat LD50: 215 mg/kg. Signs of overdose include nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, and bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis).

Fdurd Patient Information

Fdurd Organisms Affected

Humans and other mammals