Floxuridinum [Inn-Latin] en es it fr

Floxuridinum [Inn-Latin] Brand names, Floxuridinum [Inn-Latin] Analogs

Floxuridinum [Inn-Latin] Brand Names Mixture

  • No information avaliable

Floxuridinum [Inn-Latin] Chemical_Formula


Floxuridinum [Inn-Latin] RX_link


Floxuridinum [Inn-Latin] fda sheet


Floxuridinum [Inn-Latin] msds (material safety sheet)

Floxuridinum_[Inn-Latin] MSDS

Floxuridinum [Inn-Latin] Synthesis Reference

No information avaliable

Floxuridinum [Inn-Latin] Molecular Weight

246.193 g/mol

Floxuridinum [Inn-Latin] Melting Point

150.5 oC

Floxuridinum [Inn-Latin] H2O Solubility

1.19E+004 mg/L

Floxuridinum [Inn-Latin] State


Floxuridinum [Inn-Latin] LogP


Floxuridinum [Inn-Latin] Dosage Forms

Powder for solution (500mg vial)

Floxuridinum [Inn-Latin] Indication

For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.

Floxuridinum [Inn-Latin] Pharmacology

Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.

Floxuridinum [Inn-Latin] Absorption

No information avaliable

Floxuridinum [Inn-Latin] side effects and Toxicity

Oral, rat LD50: 215 mg/kg. Signs of overdose include nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, and bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis).

Floxuridinum [Inn-Latin] Patient Information

Floxuridinum [Inn-Latin] Organisms Affected

Humans and other mammals