Zydis en es it fr

Categoria

Zydis Marchi, Zydis Analoghi

Zydis Marchi miscela

  • No information avaliable
  • Zydis Formula chimica

    C17H20N4S

    Zydis RX link

    http://www.rxlist.com/cgi/generic3/symbyax.htm

    Zydis FDA foglio

    Zydis FDA

    Zydis DMS (foglio di materiale di sicurezza)

    Zydis Sintesi di riferimento

    Chakrabarti JK et al. US Pat. 5,229,382 (1991)

    Zydis Peso molecolare

    312.434 g/mol

    Zydis Temperatura di fusione

    195oC

    Zydis H2O Solubilita

    Nessuna informazione disponibile

    Zydis Stato

    Solid

    Zydis LogP

    2.199

    Zydis Forme di dosaggio

    Tablet (orale)

    Zydis Indicazione

    Per il trattamento della schizofrenia e psicosi maniaco-depressiva (disturbo bipolare).

    Zydis Farmacologia

    Olanzapina, un farmaco antipsicotico atipico, è usata per trattare sia i sintomi positivi e negativi della schizofrenia, mania acuta con disturbo bipolare, agitazione, sintomi psicotici e nella demenza. Futuro gli usi possono includere il trattamento del disturbo ossessivo-compulsivo e gravi disturbi comportamentali nell'autismo. Strutturalmente e farmacologicamente simile alla clozapina, olanzapina si lega per alfa (1), la dopamina, , H1 dell'istamina, muscarinici, e la serotonina di tipo 2 (5-HT2) recettori.

    Zydis Assorbimento

    Ben assorbito, con circa il 40% della dose è metabolizzato prima di raggiungere la circolazione sistemica.

    Zydis Tossicita

    Nessuna informazione disponibile

    Zydis Informazioni paziente

    PATIENT INFORMATION

    Physicians are advised to discuss the following issues with patients for whom they prescribe
    olanzapine:

    Orthostatic Hypotension: Patients should be advised of the risk of orthostatic hypotension,
    especially during the period of initial dose titration and in association with the use of
    concomitant drugs that may potentiate the orthostatic effect of olanzapine, e.g., diazepam
    or alcohol.

    Interference with Cognitive and Motor Performance: Because olanzapine has the potential to
    impair judgment, thinking, or motor skills, patients should be cautioned about operating
    hazardous machinery, including automobiles, until they are reasonably certain that olanzapine
    therapy does not affect them adversely.

    Pregnancy: Patients should be advised to notify their physician if they become pregnant or
    intend to become pregnant during therapy with olanzapine.

    Nursing: Patients should be advised not to breast-feed an infant if they are taking olanzapine.

    Concomitant Medication: Patients should be advised to inform their physicians if they are taking,
    or plan to take, any prescription or over-the-counter drugs, since there is a potential for
    interactions.

    Alcohol: Patients should be advised to avoid alcohol while taking olanzapine.

    Heat Exposure and Dehydration: Patients should be advised regarding appropriate care in avoiding
    overheating and dehydration.

    Phenylketonurics: ZYPREXA ZYDIS (olanzapine orally disintegrating tablets) contains phenylalanine
    (0.34, 0.45, 0.67, or 0.90 mg per 5, 10, 15, or 20mg tablet, respectively).

    Laboratory Tests

    Periodic assessment of transaminases is recommended in patients with significant hepatic disease.

    Zydis Atto interessato organismi

    Gli esseri umani e altri mammiferi