Categoria
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Analoghi
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Marchi miscela
Agro Blue (Chlorhexidine Acetate + Glycerine) Avagard Chg (Alcohol Anhydrous + Chlorhexidine Gluconate) Baxedin 2% - 70% (Chlorhexidine Gluconate + Isopropyl Alcohol) Bio Text - Liq Hos (Alcohol Anhydrous + Chlorhexidine Gluconate) Biomers - Liq Ins (Alcohol Anhydrous + Chlorhexidine Gluconate) Bioprep (Chlorhexidine Gluconate + Didecyl Dimethyl Ammonium Chloride) Bioprep Liq (Chlorhexidine Gluconate + Didecyl Dimethyl Ammonium Chloride + Isopropyl Alcohol) Biosurf - Liq Hos (Alcohol Anhydrous + Chlorhexidine Gluconate) Boston Advance Comfort Formula Conditioning Solution (Chlorhexidine Gluconate + Disodium Edetate + Polyaminopropyl Biguanide) Boston Conditioning Solution (Chlorhexidine Gluconate + Disodium Edetate) Boston Simplicity Solution - Liquid (Chlorhexidine Gluconate + Edetic Acid + Polyaminopropyl Biguanide) Boston Simplus Multi-Action Solution (Chlorhexidine Gluconate + Polyaminopropyl Biguanide) Boston?Md Conditioning Solution (Chlorhexidine Gluconate + Disodium Edetate) Burn O Sol Spray (Benzocaine + Chlorhexidine Acetate) Centaur Light Lube Gel (Chlorhexidine + Ethyl Cellulose) Chloraprep Liq 0.5% (Chlorhexidine Gluconate + Isopropyl Alcohol) Chlorhexidine 0.5% Liq (Chlorhexidine Gluconate + Isopropyl Alcohol) Chlorhexidine and Isopropyl Alcohol Prep Pads (Chlorhexidine Gluconate + Isopropyl Alcohol) Chlorhexidine and Isopropyl Alcohol Swabsticks (Chlorhexidine Gluconate + Isopropyl Alcohol) Chlorhexidine-Cetrimide Soltn Conc (Cetrimonium Bromide + Chlorhexidine Gluconate) Cida-Stat Foam (Chlorhexidine Gluconate + Isopropyl Alcohol) Cida-Stat Liq (Chlorhexidine Gluconate + Isopropyl Alcohol) Comfortcare Wetting and Soaking Solution (Chlorhexidine Gluconate + Disodium Edetate) Della-Blue Teat Dip Non-Iodine (Chlorhexidine Acetate + Glycerine) Dexidin 0.5 Solution (Chlorhexidine Gluconate + Isopropyl Alcohol) Eye and Wound Powder (Chlorhexidine Hydrochloride + Hydrocortisone Acetate + Penicillin G Procaine + Sulfathiazole) Flamazine C (Chlorhexidine Gluconate + Silver Sulfadiazine) Foam Care Chg Surgical Hand Scrub (Chlorhexidine Gluconate + Isopropyl Alcohol) G2 (Alcohol Anhydrous + Chlorhexidine Gluconate) Germi-Stat Prep Gel (Chlorhexidine Gluconate + Isopropyl Alcohol) Hexifoam-Skin Disinfectant Aer 1% (Alcohol Anhydrous + Chlorhexidine Gluconate) Hibistat Germicidal Hand Rinse (Chlorhexidine Gluconate + Isopropyl Alcohol) Hx Dip (Post Milking Teat Dip) (Chlorhexidine Acetate + Glycerine) Hx Dip Lv (Post Milking Teat Dip) (Chlorhexidine Acetate + Glycerine) Ic-Gel (Chlorhexidine Gluconate + Isopropyl Alcohol) Inhibidex (Chlorhexidine Acetate + Glycerine) Lines (Alcohol Anhydrous + Chlorhexidine Gluconate) Mediwipe Pad (Chlorhexidine Gluconate + Phenoxyethanol) Ready Wipe (Alcohol Anhydrous + Chlorhexidine Acetate) Roby F60 Chlorhexidine Teat Dip (Chlorhexidine Acetate + Glycerine) Salvesept Crm (Cetrimonium Bromide + Chlorhexidine Gluconate) Sanhexidine Liq (Chlorhexidine Acetate + Glycerine + Lanolin) Sanidip (Chlorhexidine Acetate + Glycerine) Sanifilm (Chlorhexidine Acetate + Glycerine) Savlodil (Single Use) (Cetrimide + Chlorhexidine Gluconate) Savlon Hospital Concentrate (Cetrimide + Chlorhexidine Gluconate) Savlon Hospital Concentrate Disinf Liq (Cetrimonium Bromide + Chlorhexidine Gluconate) Scrub-Stat Iv 4% (Chlorhexidine Gluconate + Isopropyl Alcohol) Septefx (18.5%) (Alcohol Anhydrous + Chlorhexidine Gluconate + Edetic Acid) Septefx (70.5%) (Alcohol Anhydrous + Chlorhexidine Gluconate + Edetic Acid) Septi-San (Chlorhexidine Gluconate + Didecyl Dimethyl Ammonium Chloride) Soft Care Antiseptic Hand Soap (Chlorhexidine Gluconate + Didecyl Dimethyl Ammonium Chloride) Solu-I.V. Chg-Alcohol (Chlorhexidine Gluconate + Isopropyl Alcohol) Solu-I.V. Tiges Montees Chd Alcool - Stk (Chlorhexidine Gluconate + Isopropyl Alcohol) Solu-Iv Chd-Alcool Tampon (Chlorhexidine Gluconate + Isopropyl Alcohol) Soluprep Chd-Alcohol-Spg-Liq (Chlorhexidine Gluconate + Isopropyl Alcohol) Spectro Tar Antiseptic Shampoo (Chlorhexidine Gluconate + Coal Tar) Stanhexidine 2% with Isopropyl Alcohol 4% (Chlorhexidine Gluconate + Isopropyl Alcohol) Stanhexidine 4% with Isopropyl Alcohol 4% (Chlorhexidine Gluconate + Isopropyl Alcohol) Stanhexidine Aqueous 2% with 4% Isopropyl Alcohol (Chlorhexidine Gluconate + Isopropyl Alcohol) Stanhexidine Untinted Tincture 0.5% W Alco (Chlorhexidine Gluconate + Isopropyl Alcohol) Steri-Stat Liq 4.0% (Chlorhexidine Gluconate + Isopropyl Alcohol) Steri-Stat Tincture (Tinted) Antis Prep Gel (Chlorhexidine Gluconate + Isopropyl Alcohol) Sterigel (Alcohol Anhydrous + Chlorhexidine Gluconate) Stomadhex C-100 (Chlorhexidine Acetate + Nicotinamide) Stomadhex C-300 (Chlorhexidine Acetate + Nicotinamide) Swiffer Wetjet Antibacterial Floor Cleaner (Chlorhexidine Acetate + Didecyl Dimethyl Ammonium Chloride) Ultra Dip (Chlorhexidine Acetate + Glycerine) Ultra Dip Ext (Chlorhexidine Acetate + Glycerine) Ultra Dip LV (Chlorhexidine Acetate + Glycerine) Ultrastat (Chlorhexidine Hydrochloride + Sodium Alginate)
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Formula chimica
C22H30Cl2N10
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RX link
http://www.rxlist.com/cgi/generic2/chlorhexidine.htm
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FDA foglio
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DMS (foglio di materiale di sicurezza)
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Sintesi di riferimento
Rose, Swain, J. Chem. Soc. 1956, 4422; US Pat. 2,684,924 (1954)
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Peso molecolare
505.446 g/mol
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Temperatura di fusione
134 oC
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H2O Solubilita
0,08% (w / v)
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Stato
Solid
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LogP
4.066
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Forme di dosaggio
Risciacquo orale; pellet (a rilascio prolungato); Periochip (in una matrice biodegradabile di gelatina idrolizzata reticolato con glutaraldeide), Crema, Spogliatoio, gel, lozione, unguento; Spugna
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Indicazione
Per la riduzione della profondità della tasca nei pazienti affetti da parodontite, usato come terapia aggiuntiva alla scala e alle procedure levigatura radicolare. Anche per la prevenzione della carie dentale, decontaminazione orofaringea in modo critico malati, l'igiene delle mani in personale sanitario, detergente generale, e preparazione del sito del catetere e cura.
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Farmacologia
Clorexidina, un agente antimicrobico topico, è battericida. A causa della sua carica positiva, la molecola clorexidina reagisce con la superficie delle cellule microbiche a distruggere l'integrità della membrana cellulare. . Questo nuovo meccanismo d'azione lo rende altamente improbabile per lo sviluppo di resistenza batterica.
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Assorbimento
L'assorbimento di clorexidina dal tratto gastrointestinale è molto povera. Inoltre, uno studio in vivo in 18 pazienti adulti non ha trovato concentrazioni plasmatiche rilevabili o clorexidina urine in seguito all'inserimento di quattro impianti parodontale in condizioni cliniche.
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Tossicita
LD50 = 2g/kg (umane, orale); LD50 = 3 g / kg (ratto, orale); LD50 = 2,5 g / kg (topo, orale); LD50 = 21 mg / kg (ratto maschio, IV); LD50 = 23 mg / kg (ratto femmina, IV); LD50 = 25 mg / kg (topo maschio, IV); LD50 = 24 mg / kg (femmina topi, IV); LD50 = 1g/kg (ratto, per via sottocutanea); LD50 = 637 mg / kg (topo maschio, per via sottocutanea); LD50 = 632 mg / kg (femmine di topo, per via sottocutanea)
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Informazioni paziente
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Atto interessato organismi
Batteri
