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Mytozytrex Marchi, Mytozytrex Analoghi

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  • Mytozytrex Formula chimica

    C15H18N4O5

    Mytozytrex RX link

    http://www.rxlist.com/cgi/generic3/mitomycin.htm

    Mytozytrex FDA foglio

    Mytozytrex FDA

    Mytozytrex DMS (foglio di materiale di sicurezza)

    Mytozytrex MSDS

    Mytozytrex Sintesi di riferimento

    Uzu et al;. Agric.Biol.Chem;. 28, 394401 (1964)

    Mytozytrex Peso molecolare

    334.327 g/mol

    Mytozytrex Temperatura di fusione

    > 360 oC

    Mytozytrex H2O Solubilita

    Solubile (8430 mg / L)

    Mytozytrex Stato

    Solid

    Mytozytrex LogP

    -2.347

    Mytozytrex Forme di dosaggio

    Iniezione (5, 20, 40 mg / flaconcino)

    Mytozytrex Indicazione

    Per il trattamento delle neoplasie maligne del labbro, cavità orale, faringe, organi digestivi, peritoneo, seno femminile, e della vescica urinaria.

    Mytozytrex Farmacologia

    Mitomicina è uno dei farmaci chemioterapici più anziani, che è stato in giro e in uso da decenni. Si tratta di un antibiotico che ha dimostrato di avere attività antitumorale. Mitomicina inibisce selettivamente la sintesi di acido desossiribonucleico (DNA). Il contenuto di guanina e citosina correla con il grado di mitomicina indotta cross-linking. Ad alte concentrazioni del farmaco, RNA cellulare e la sintesi proteica sono anche soppresso. Mitomicina è stato dimostrato in vitro di inibire cellule B, cellule T e la proliferazione dei macrofagi e mettere in pericolo presentazione dell'antigene, così come la secrezione di interferone gamma, TNFa e IL-2. .

    Mytozytrex Assorbimento

    Irregolare.

    Mytozytrex Tossicita

    Orale, mouse: LD50 = 23 mg / kg, orale, ratto: LD50 = 30 mg / kg. Sintomi di sovradosaggio comprendono nausea e vomito.

    Mytozytrex Informazioni paziente

    mitomycin C, Mutamycin

    Mitomycin (my-toe-MY-sin) is a drug that is used to treat many kinds of cancer. It
    is a clear blue or purple liquid that is injected into a vein.
    A blood sample will be taken before each treatment. The dose and timing of your
    chemotherapy may be changed based on your blood counts and/or other side effccts.
    Other drugs may interact with mitomycin. Tell your doctor if you are taking any
    other drugs as your dose may need to be changed. Check with your doctor or pharmacist
    before you start taking any new drugs.
    The drinking of alcohol (in small amounts) will not affect the safety or usefulness of
    mitomycin.
    Mitomycin may damage sperm and may harm the baby if used during pregnancy. It is best
    to use birth control while being treated with mitomycin. Tell your doctor right away
    if you or your partner becomes pregnant. Do not breast feed during treatment.
    Tell doctors or dentists that you are being treated with mitomycin before you receive
    any treatment from them.
    SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:

    Signs of an infection such as fever (over 100F or 38C); chills; cough; sore throat;
    pain or burning when you pass urine; redness, pain or swelling of any area of your body;
    sores forming anywhere on your body.
    Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint red
    spots on skin.

    SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:

    Severe skin reaction where you have had radiation.
    Signs of anemia such as unusual tiredness or weakness.
    Signs of lung problems such as dry cough, shortness of breath or problems breathing.
    This may occur up to several months after treatment.
    Signs of kidney problems such as decreased urine, blood in urine, swelling of feet
    or legs. This may occur up to several months after treatment.

    CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:

    Uncontrolled nausea, vomiting or loss of appetite.
    Easy bruising or bleeding.
    Redness, swelling, pain or sores where the needle was placed.
    Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
    Skin rash.

    REPORT ADDITIONAL PROBLEMS TO YOUR DOCTOR.

    See Chemotherapy and You: a Guide to Self-help During Treatment available free from
    the Canadian Cancer Society for more information on managing side effects.

    Mytozytrex Atto interessato organismi

    Gli esseri umani e altri mammiferi