Mitomycin C (JP14)

• Antibiotics, Antineoplastic
• Alkylating Agents
• Cross-Linking Reagents
• Nucleic Acid Synthesis Inhibitors
• ATC:L01DC03

• 7-Amino-9α-methoxymitosane
• Ametycin
• Ametycine
• MMC
• Mit-C
• Mitamycin
• Mito-C
• Mitocin-C
• Mitomycin (TN)
• Mitomycin (USAN)
• Mitomycin C
• Mitomycin C (JP14)
• Mitomycin C/NaCl
• Mitomycin [USAN:BAN:INN]
• Mitomycin-C
• Mitomycinum
• Mitomycinum C
• Mitomycyna C [Polish]
• Mitozytrex
• Muamycin
• Muamycin (TN)
• Mutamycin
• Mytomycin
• Mytozytrex

No information avaliable

C₁₅H₁₈N₄O₅

http://www.rxlist.com/cgi/generic3/mitomycin.htm

Mitomycin_C_(JP14) FDA

Mitomycin_C_(JP14) MSDS

Uzu et al;. Agric.Biol.Chem;. 28, 394401 (1964)

334.327 g/mol

> 360 ^oC

Solubile (8430 mg / L)

Solid

-2.347

Iniezione (5, 20, 40 mg / flaconcino)

Per il trattamento delle neoplasie maligne del labbro, cavità orale, faringe, organi digestivi, peritoneo, seno femminile, e della vescica urinaria.

Mitomicina è uno dei farmaci chemioterapici più anziani, che è stato in giro e in uso da decenni. Si tratta di un antibiotico che ha dimostrato di avere attività antitumorale. Mitomicina inibisce selettivamente la sintesi di acido desossiribonucleico (DNA). Il contenuto di guanina e citosina correla con il grado di mitomicina indotta cross-linking. Ad alte concentrazioni del farmaco, RNA cellulare e la sintesi proteica sono anche soppresso. Mitomicina è stato dimostrato in vitro di inibire cellule B, cellule T e la proliferazione dei macrofagi e mettere in pericolo presentazione dell'antigene, così come la secrezione di interferone gamma, TNFa e IL-2. .

Irregolare.

Orale, mouse: LD50 = 23 mg / kg, orale, ratto: LD50 = 30 mg / kg. Sintomi di sovradosaggio comprendono nausea e vomito.

mitomycin C, Mutamycin�

Mitomycin (my-toe-MY-sin) is a drug that is used to treat many kinds of cancer. It
is a clear blue or purple liquid that is injected into a vein.
A blood sample will be taken before each treatment. The dose and timing of your
chemotherapy may be changed based on your blood counts and/or other side effccts.
Other drugs may interact with mitomycin. Tell your doctor if you are taking any
other drugs as your dose may need to be changed. Check with your doctor or pharmacist
before you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or usefulness of
mitomycin.
Mitomycin may damage sperm and may harm the baby if used during pregnancy. It is best
to use birth control while being treated with mitomycin. Tell your doctor right away
if you or your partner becomes pregnant. Do not breast feed during treatment.
Tell doctors or dentists that you are being treated with mitomycin before you receive
any treatment from them.
SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:

Signs of an infection such as fever (over 100�F or 38�C); chills; cough; sore throat;
pain or burning when you pass urine; redness, pain or swelling of any area of your body;
sores forming anywhere on your body.
Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint red
spots on skin.

SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:

Severe skin reaction where you have had radiation.
Signs of anemia such as unusual tiredness or weakness.
Signs of lung problems such as dry cough, shortness of breath or problems breathing.
This may occur up to several months after treatment.
Signs of kidney problems such as decreased urine, blood in urine, swelling of feet
or legs. This may occur up to several months after treatment.

CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:

Uncontrolled nausea, vomiting or loss of appetite.
Easy bruising or bleeding.
Redness, swelling, pain or sores where the needle was placed.
Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
Skin rash.

REPORT ADDITIONAL PROBLEMS TO YOUR DOCTOR.

See Chemotherapy and You: a Guide to Self-help During Treatment available free from
the Canadian Cancer Society for more information on managing side effects.

Gli esseri umani e altri mammiferi