Evista
Categoria
Evista Marchi, Evista Analoghi
Evista Marchi miscela
Evista Formula chimica
C28H27NO4S
Evista RX link
http://www.rxlist.com/cgi/generic/raloxif.htm
Evista FDA foglio
Evista DMS (foglio di materiale di sicurezza)
Evista Sintesi di riferimento
CD Jones et al. J. Med. Cem. 27, 1057 (1984)
Evista Peso molecolare
473.584 g/mol
Evista Temperatura di fusione
143-147oC
Evista H2O Solubilita
0,25 mg / L
Evista Stato
Solid
Evista LogP
5.749
Evista Forme di dosaggio
Compressa
Evista Indicazione
Per la prevenzione dell'osteoporosi nelle donne in postmenopausa
Evista Farmacologia
Raloxifene, un modulatore selettivo del recettore dell'estrogeno (SERM) della classe benzotiofene, è simile al tamoxifene in quanto produce estrogeno-simile effetti sul metabolismo osseo e dei lipidi, mentre antagonizzare gli effetti degli estrogeni sul tessuto mammario. Raloxifene riduce il riassorbimento osseo, aumenta la densità minerale ossea (BMD) e riduce l'incidenza di fratture. Il raloxifene è utilizzato nella prevenzione della menopausa l'osteoporosi e il cancro al seno.
Evista Assorbimento
Circa il 60% di una dose orale viene assorbita, ma glucuronoconiugazione presistemica è ampia. La biodisponibilità assoluta del raloxifene è pari a 2,0%
Evista Tossicita
Nessuna informazione disponibile
Evista Informazioni paziente
PATIENT INFORMATION
For safe and effective use of EVISTA, the physician should inform patients about the following:
Patient Immobilization: EVISTA should be discontinued at least 72 hours prior to and during prolonged immobilization
(e.g., post-surgical recovery, prolonged bed rest), and patients should be advised to avoid prolonged restrictions of
movement during travel because of the increased risk of venous thromboembolic events.
Hot flashes or flushes: EVISTA is not effective in reducing hot flashes or flushes associated with estrogen deficiency.
In some asymptomatic patients, hot flashes may occur upon beginning EVISTA therapy.
Other Preventive Measures: Patients should be instructed to take supplemental calcium and vitamin D, if daily dietary
intake is inadequate. Weight-bearing exercise should be considered along with the modification of certain behavioral
factors, such as cigarette smoking, and/or alcohol consumption, if these factors exist.
Physicians should instruct their patients to read the patient package insert before starting therapy with EVISTA and to
re-read it each time the prescription is renewed.
For safe and effective use of EVISTA, the physician should inform patients about the following:
Patient Immobilization: EVISTA should be discontinued at least 72 hours prior to and during prolonged immobilization
(e.g., post-surgical recovery, prolonged bed rest), and patients should be advised to avoid prolonged restrictions of
movement during travel because of the increased risk of venous thromboembolic events.
Hot flashes or flushes: EVISTA is not effective in reducing hot flashes or flushes associated with estrogen deficiency.
In some asymptomatic patients, hot flashes may occur upon beginning EVISTA therapy.
Other Preventive Measures: Patients should be instructed to take supplemental calcium and vitamin D, if daily dietary
intake is inadequate. Weight-bearing exercise should be considered along with the modification of certain behavioral
factors, such as cigarette smoking, and/or alcohol consumption, if these factors exist.
Physicians should instruct their patients to read the patient package insert before starting therapy with EVISTA and to
re-read it each time the prescription is renewed.
Evista Atto interessato organismi
Gli esseri umani e altri mammiferi
