Anandron

• Androgen Antagonists
• Antineoplastic Agents
• ATC:L02BB02

• Anandron
• Nilandron
• Nilandrone
• Nilutamida [Spanish]
• Nilutamide [Usan:Ban:Inn]
• Nilutamidum [Latin]

No information avaliable

C₁₂H₁₀F₃N₃O₄

http://www.rxlist.com/cgi/generic2/nilutam.htm

Nessuna informazione disponibile

317.221 g/mol

No information avaliable

Nessuna informazione disponibile

Solid

2.232

Compressa

Per l'uso in combinazione con la castrazione chirurgica per il trattamento del carcinoma della prostata metastatico (stadio D2)

Nilutamide è un farmaco antineoplastico ormonali utilizzati principalmente nel trattamento del cancro alla prostata. Nilutamide è un puro, farmaci anti-androgeni con affinità per i recettori degli androgeni (ma non per progesterone, estrogeni o recettori glucocorticoidi). Di conseguenza, Nilutamide blocca l'azione degli androgeni di origine surrenalica e ai testicoli che stimolano la crescita dei normali e maligni del tessuto prostatico. Prostata il cancro è in gran parte androgeno-dipendente e possono essere trattati con castrazione chirurgica o chimica. Ad oggi, la monoterapia con antiandrogeni non ha sempre dimostrato di essere equivalente a castrazione.

Rapidamente e completamente assorbito, ottenendo le concentrazioni plasmatiche elevate e persistenti.

Sintomi di sovradosaggio includere vertigini, malessere generale, cefalea, nausea e vomito.

Patients should be informed that NILANDRON tablets should be started on the day of, or on the day after, surgical castration. They should also be informed that they should not interrupt their dosing of NILANDRON or stop taking this medication without consulting their physician.
Because of the possibility of interstitial pneumonitis, patients should also be told to report immediately any dyspnea or aggravation of pre-existing dyspnea.

Because of the possibility of hepatitis, patients should be told to consult with their physician should nausea, vomiting, abdominal pain, or jaundice occur.
Because of the possibility of an intolerance to alcohol (facial flushes, malaise, hypotension) following ingestion of NILANDRON, it is recommended that intake of alcoholic beverages be avoided by patients who experience this reaction. This effect has been reported in about 5% of patients treated with NILANDRON.

In clinical trials, 13% to 57% of patients receiving NILANDRON reported a delay in adaptation to dark, ranging from seconds to a few minutes, when passing from a lighted area to a dark area. This effect sometimes does not abate as drug treatment is continued. Patients who experience this effect should be cautioned about driving at night or through tunnels. This effect can be alleviated by the wearing of tinted glasses.

Gli esseri umani e altri mammiferi