Categorie
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Les marques,
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Analogs
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Les marques melange
No information avaliable
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Formule chimique
C10H15N5O3
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RX lien
http://www.rxlist.com/cgi/generic3/penciclovir.htm
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FDA fiche
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msds (fiche de securite des materiaux)
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Synthese de reference
RL Jarvest, MR Harnden, le brevet américain. . 5,075,445 (1991)
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Poids moleculaire
253.258 g/mol
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Point de fusion
275-277 oC
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H2O Solubilite
1.7mg/ml
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Etat
Solid
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LogP
-1.62
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Formes pharmaceutiques
Crème topique
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Indication
Utilisé pour traiter les plaies récurrentes froide sur les lèvres et le visage.
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Pharmacologie
Le penciclovir est le métabolite actif du produit par voie orale de famciclovir. Les résultats plus favorables observés avec l'acyclovir actualité penciclovir par rapport topique pour le traitement de l'herpès labial peut être dû à la intracellulaire plus longue demi-vie de penciclovir au HSV-cellules infectées.
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Absorption
Concentrations mesurables penciclovir n'a été détectée dans le plasma ou l'urine des volontaires mâles sains (n = 12) après l'application simple ou répétition de la crème à 1% à une dose de 180 mg par jour penciclovir.
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Toxicite
Les symptômes de surdose comprennent des céphalées, des douleurs abdominales, augmentation de la lipase sérique, les nausées, la dyspepsie, des étourdissements et une hyperbilirubinémie.
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Information pour les patients
PATIENT INFORMATION
Penciclovir
About Penciclovir
This belongs to the group of medicines known as antivirals.
It is used to treat infections caused by the Herpes simplex virus, such as cold sores.
Penciclovir is available in cream form.
It is also sometimes known as: Vectavir. You may notice the use of any of these names on the packaging of your medicine.
Before using Penciclovir
Before using any penciclovir cream make sure your doctor or pharmacist knows:
if you have ever had an allergic reaction to this or any other medicine
if you are using any other preparations, including those available to buy without a prescription, herbal and complementary
medicines
How to use Penciclovir
Use penciclovir cream exactly as directed by your doctor.
Always read the manufacturer's information leaflet, if possible, before beginning treatment.
Apply penciclovir cream every two hours while you are awake, for four days, unless otherwise directed by your doctor.
This medicine is for you. Never give it to others, even if their condition appears to be the same as yours.
Getting the most from your treatment
Penciclovir cream is best used as soon as possible after the symptoms of an infection begin (e.g. pain, burning or blisters).
Always wash and dry your hands thoroughly before and after handling penciclovir cream.
Complete the prescribed course of treatment with penciclovir, otherwise your infection is likely to recur. Treatment with
penciclovir cream usually lasts four days.
Before using any 'over-the-counter' medicines, check with your pharmacist which medicines are safe for you to use alongside
penciclovir cream.
You should see an improvement in your condition after a few days. If your condition does not seem to be getting better after
four days, consult your doctor for advice.
Can Penciclovir cause problems?
Penciclovir cream occasionally causes skin irritation such as stinging, burning and numbness. This should soon disappear. If
it doesn't or if it becomes severe, stop using penciclovir and ask your doctor or pharmacist for advice.
If you experience any other worrying symptoms, which you think may be due to this preparation, consult your doctor or
pharmacist.
How to store Penciclovir
Keep out of reach of children.
Store in a cool, dry place, away from direct light and heat.
Never keep out of date or unwanted medicines. Discard them safely out of the reach of children or take them to your local
pharmacist who will dispose of unwanted medicines for you.
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Organismes affectes
Herpes simplex virus