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FK5 Les marques, FK5 Analogs

FK5 Les marques melange

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  • FK5 Formule chimique

    C44H69NO12

    FK5 RX lien

    http://www.rxlist.com/cgi/generic2/tacrolimus.htm

    FK5 FDA fiche

    FK5 FDA

    FK5 msds (fiche de securite des materiaux)

    FK5 MSDS

    FK5 Synthese de reference

    Aucune information disponible

    FK5 Poids moleculaire

    804.018 g/mol

    FK5 Point de fusion

    126 oC

    FK5 H2O Solubilite

    Insolubles

    FK5 Etat

    Solid

    FK5 LogP

    3.534

    FK5 Formes pharmaceutiques

    Capsule; Pommade; Solution

    FK5 Indication

    Pour utiliser après transplantation d'organe allogénique pour réduire l'activité du système immunitaire du patient et donc le risque de rejet d'organe. Il a d'abord été approuvé par la FDA en 1994 pour une utilisation en transplantation hépatique, cela a été élargie pour inclure des reins, du coeur, intestin grêle, du pancréas, du poumon, la trachée, de la peau, la cornée et les greffes de membres. Il a également été utilisée dans une préparation topique dans le traitement des atopique sévère dermatite.

    FK5 Pharmacologie

    Le tacrolimus est un antibiotique macrolide. Il agit en réduisant l'activité peptidyl-prolyl isomérase en se liant à l'immunophiline FKBP-12 (FK506 binding protein) la création d'un nouveau complexe. Cette inhibe à la fois T- transduction du signal des lymphocytes et l'IL-2 de la transcription. Bien que cette activité est similaire à la cyclosporine des études ont montré que l'incidence du rejet aigu est réduit par l'utilisation du tacrolimus sur la cyclosporine. Le tacrolimus a également été montré pour être efficace dans le traitement topique de l'eczéma, l'eczéma atopique particulier. Il supprime l'inflammation d'une manière similaire à des stéroïdes, mais n'est pas aussi puissant. Une importante Profitez dermatologiques de tacrolimus est qu'il peut être utilisé directement sur le visage; stéroïdes topiques ne peut pas être utilisé sur le visage, comme ils amincir la peau de façon spectaculaire là-bas. Sur d'autres parties du corps, d'actualité stéroïdes sont généralement un meilleur traitement.

    FK5 Absorption

    20% la biodisponibilité; moins après avoir mangé des aliments riches en matières grasses

    FK5 Toxicite

    Les effets secondaires peuvent être graves et comprennent des problèmes de vision floue, le foie et les reins (il est néphrotoxique), des convulsions, des tremblements, de l'hypertension, l'hypomagnésémie, le diabète sucré, l'hyperkaliémie, des démangeaisons, insomnie, confusion. DL50 = 134-194 mg / kg (rat).

    FK5 Information pour les patients

    Read this important information before you start using PROTOPIC [pro-TOP-ik] Ointment and each time you refill your prescription. There may be new information. This summary is not meant to take the place of your doctorís advice.

    What Is PROTOPIC?
    PROTOPIC Ointment is a prescription medicine that is used to treat eczema (atopic dermatitis). It is for adults and children age 2 years and older. You can use PROTOPIC for short or intermittent long periods of treatment. Intermittent means starting and stopping repeatedly, as directed by your doctor. You can use it on all affected areas of your skin, including your face and neck.

    Who should not use PROTOPIC? Do not use PROTOPIC if you are

    ï breastfeeding

    ï allergic to PROTOPIC Ointment or any of its ingredients. The active ingredient is tacrolimus. Ask your doctor or pharmacist about the inactive ingredients.

    Before you start using PROTOPIC, tell your doctor if you are:

    ï using any other prescription medicines, non-prescription (over-the-counter) medicines, or supplements

    ï receiving any form of light therapy (phototherapy, UVA or UVB) on your skin

    ï using any other type of skin product ï pregnant or planning to become pregnant

    How Do I Use PROTOPIC?
    Use PROTOPIC only to treat eczema that has been diagnosed by a doctor.

    ï Wash your hands before using PROTOPIC.

    ï Apply a thin layer of PROTOPIC to all skin areas that your doctor has diagnosed as eczema. Try to cover the affected areas completely. Most people find that a pea-sized amount squeezed from the tube covers an area about the size of a two-inch circle (approximately the size of a silver dollar).

    ï Apply the ointment twice a day, about 12 hours apart.

    ï Before applying PROTOPIC Ointment after a bath or shower, be sure your skin is completely dry.

    ï Do not cover the skin being treated with bandages, dressings or wraps. Unless otherwise instructed by your doctor, do not apply another type of skin product on top of PROTOPIC Ointment. However, you can wear normal clothing.

    ï Do not bathe, shower or swim right after applying PROTOPIC. This could wash off the ointment.

    ï If you are a caregiver applying PROTOPIC Ointment to a patient, or if you are a patient who is not treating your hands, wash your hands with soap and water after applying PROTOPIC. This should remove any ointment left on the hands.

    ï Use PROTOPIC only on your skin. Do not swallow PROTOPIC.

    Because 2 strengths of PROTOPIC are available for adult patients, your doctor will decide what strength of PROTOPIC Ointment is best for you.

    Many people notice that their skin starts to improve after the first few weeks of treatment. Even though your skin looks and feels better, it is important to keep using PROTOPIC as instructed by your doctor.

    If you do not notice an improvement in your eczema or if your eczema gets worse within the first few weeks of treatment, tell your doctor.

    What Should I Avoid While Using PROTOPIC?

    ï Avoid sunlight and sun lamps, tanning beds, and treatment with UVA or UVB light. If you need to be outdoors after applying PROTOPIC, wear loose fitting clothing that protects the treated area from the sun. In addition, ask your doctor what other type of protection from the sun you should use.

    ï Check with your doctor or pharmacist before you

    ï start taking any new medicines while using PROTOPIC.

    ï Start using any other ointment, lotions, or creams on your skin.

    What Are The Possible Side Effects of PROTOPIC?

    The most common side effects of PROTOPIC are stinging, soreness, a burning feeling, or itching of the skin treated with PROTOPIC. These side effects are usually mild to moderate, are most common during the first few days of treatment, and typically lessen if your skin heals.

    Less common side effects include acne, swollen or infected hair follicles, headache, increased sensitivity of the skin to hot or cold temperatures, or flu-like symptoms [common cold and congestion (stuffy nose)]. Some people may get skin tingling, upset stomach, herpes zoster (chicken pox or shingles), or muscle pain. While you are using PROTOPIC, drinking alcohol may cause the skin or face to become flushed or red and feel hot. Call your doctor if side effects continue or become a problem.

    How Should I Store PROTOPIC?

    Store PROTOPIC at room temperature (59° to 86°F). For instance, never leave PROTOPIC in your car in cold or hot weather. Make sure the cap on the tube is tightly closed. Keep PROTOPIC out of the reach of children.

    General Advice about Prescription Medicines

    Do not use PROTOPIC for a condition for which it was not prescribed. If you have any concerns about PROTOPIC, ask your doctor. Your doctor or pharmacist can give you information about PROTOPIC that was written for health care professionals. For more information, you can also visit the Fujisawa Internet site at www.fujisawa.com or call the PROTOPIC Help Line at 1-800-727-7003.

    FK5 Organismes affectes

    Les humains et autres mammifères