Categorie
Diphenoxylate Hydrochloride
Les marques,
Diphenoxylate Hydrochloride
Analogs
Diphenoxylate Hydrochloride
Les marques melange
Lomotil (Atropine Sulfate + Diphenoxylate Hcl)
Diphenoxylate Hydrochloride
Formule chimique
C30H32N2O2
Diphenoxylate Hydrochloride
RX lien
http://www.rxlist.com/cgi/generic3/diphenoxylate.htm
Diphenoxylate Hydrochloride
FDA fiche
Diphenoxylate Hydrochloride
msds (fiche de securite des materiaux)
Diphenoxylate Hydrochloride
Synthese de reference
Janssen, le brevet américain. 2,898,340 (1959)
Diphenoxylate Hydrochloride
Poids moleculaire
452.587 g/mol
Diphenoxylate Hydrochloride
Point de fusion
221 oC
Diphenoxylate Hydrochloride
H2O Solubilite
0,8 mg / ml
Diphenoxylate Hydrochloride
Etat
Solid
Diphenoxylate Hydrochloride
LogP
7.385
Diphenoxylate Hydrochloride
Formes pharmaceutiques
Solution orale; Tablet
Diphenoxylate Hydrochloride
Indication
Pour la thérapie comme traitement d'appoint dans le traitement de la diarrhée
Diphenoxylate Hydrochloride
Pharmacologie
Diphénoxylate, un anti-diarrhéique, est efficace comme thérapie adjuvante dans le traitement de la diarrhée. Diphénoxylate est rapidement et largement métabolisé chez l'homme par hydrolyse de l'ester de l'acide diphenoxylic (difenoxine), qui est biologiquement active et le principal métabolite dans le sang.
Diphenoxylate Hydrochloride
Absorption
90%
Diphenoxylate Hydrochloride
Toxicite
Coma, peau et muqueuses sèches, dilatation des pupilles des yeux, la température du corps extrêmement élevée, bouffées vasomotrices, mouvements du globe oculaire involontaire, inférieure à la normale du tonus musculaire, rétrécissement des pupilles, un pouls rapide, de l'agitation, la morosité, supprimé la respiration
Diphenoxylate Hydrochloride
Information pour les patients
INFORM THE PATIENT (PARENT OR GUARDIAN) NOT TO EXCEED THE RECOMMENDED DOSAGE AND TO KEEP DIPHEN-OXYLATE HCL AND
ATROPINE SULFATE OUT OF THE REACH OF CHILDREN AND IN A CHILD-RESISTANT CONTAINER, INFORM THE PATIENT OF THE
CONSEQUENCES OF OVERDOSAGE, INCLUDING SEVERE RESPIRATORY DEPRESSION AND COMA, POSSIBLY LEADING TO PERMANENT BRAIN
DAMAGE OR DEATH.
Diphenoxylate HCl and atropine sulfate may produce drowsiness or dizziness. The patient should be cautioned
regarding activities requiring mental alertness, such as driving or operati ng dangerous machinery. Potentiation of
the action of alcohol, barbiturates and tranquilizers with concomitant use of diphenoxylate HCl and atropine sulfate
should be explained to the patient. The physician should also provide the patient with other information in this
labeling, as appropriate.
Diphenoxylate Hydrochloride
Organismes affectes
Les humains et autres mammifères