Diphenoxalate

Diphenoxalate Brand names, Diphenoxalate Analogs

Diphenoxalate Brand Names Mixture

Lomotil (Atropine Sulfate + Diphenoxylate Hcl)

Diphenoxalate Chemical_Formula

C₃₀H₃₂N₂O₂

Diphenoxalate RX_link

http://www.rxlist.com/cgi/generic3/diphenoxylate.htm

Diphenoxalate fda sheet

Diphenoxalate msds (material safety sheet)

Diphenoxalate MSDS

Diphenoxalate Synthesis Reference

Janssen, U.S. pat. 2,898,340 (1959)

Diphenoxalate Molecular Weight

452.587 g/mol

Diphenoxalate Melting Point

221 ^oC

Diphenoxalate H₂O Solubility

0.8 mg/ml

Diphenoxalate State

Solid

Diphenoxalate LogP

7.385

Diphenoxalate Dosage Forms

Oral solution; Tablet

Diphenoxalate Indication

For as adjunctive therapy in the management of diarrhea

Diphenoxalate Pharmacology

Diphenoxylate, an antidiarrheal, is effective as adjunctive therapy in the management of diarrhea. Diphenoxylate is rapidly and extensively metabolized in man by ester hydrolysis to diphenoxylic acid (difenoxine), which is biologically active and the major metabolite in the blood.

Diphenoxalate Absorption

90%

Diphenoxalate side effects and Toxicity

Coma, dry skin and mucous membranes, enlarged pupils of the eyes, extremely high body temperature, flushing, involuntary eyeball movement, lower than normal muscle tone, pinpoint pupils, rapid heartbeat, restlessness, sluggishness, suppressed breathing

Diphenoxalate Patient Information

INFORM THE PATIENT (PARENT OR GUARDIAN) NOT TO EXCEED THE RECOMMENDED DOSAGE AND TO KEEP DIPHEN-OXYLATE HCL AND ATROPINE SULFATE OUT OF THE REACH OF CHILDREN AND IN A CHILD-RESISTANT CONTAINER, INFORM THE PATIENT OF THE CONSEQUENCES OF OVERDOSAGE, INCLUDING SEVERE RESPIRATORY DEPRESSION AND COMA, POSSIBLY LEADING TO PERMANENT BRAIN DAMAGE OR DEATH.

Diphenoxylate HCl and atropine sulfate may produce drowsiness or dizziness. The patient should be cautioned regarding activities requiring mental alertness, such as driving or operati ng dangerous machinery. Potentiation of the action of alcohol, barbiturates and tranquilizers with concomitant use of diphenoxylate HCl and atropine sulfate should be explained to the patient. The physician should also provide the patient with other information in this labeling, as appropriate.

Diphenoxalate Organisms Affected

Humans and other mammals