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Analogs
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Alka Seltzer Plus Cold Medicine Evt (Acetylsalicylic Acid + Chlorpheniramine Maleate + Phenylpropanolamine Bitartrate) Alka-Seltzer Plus Cold Medicine - Evt (Acetylsalicylic Acid + Chlorpheniramine Maleate + Phenylpropanolamine Bitartrate) Antitussive Decong Antihistamine Syr (Dextromethorphan Hydrobromide + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate) Bronchodex D Cap (Chlorpheniramine Maleate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride) Bronchosirum Pour Enfants (Dextromethorphan Hydrobromide + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate) Caldomine Dh Adulte (Hydrocodone Bitartrate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate) Caldomine Dh Enfant (Hydrocodone Bitartrate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate) Centracol DM - Syr (Dextromethorphan Hydrobromide + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate) Chlor Tripolon Decongest Syr (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Cold & Allergy (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Cold & Allergy Relief - Liq (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Cold Decongestant Long Acting Cap (Chlorpheniramine Maleate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride) Cold Relief (Brompheniramine Maleate + Phenylpropanolamine Hydrochloride) Cold Relief DM (Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylpropanolamine Hydrochloride) Coltalin Tablet (Acetaminophen + Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Contac Cold Capsules (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Contac Cold Extra Strength Capsules (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Contac Cough Cold and Flu Caplets (Acetaminophen + Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Phenylpropanolamine Hydrochloride) Contact C Src (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Coricidin D Long Acting Tab (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Coricidin D Tab (Acetylsalicylic Acid + Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Coricidin Nd Tab (Acetylsalicylic Acid + Phenylpropanolamine Hydrochloride) Coricidin Sinus Headache Tab (Acetaminophen + Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Corsym Suspension (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Cough, Cold & Allergy Relief (Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Counteract Sinus and Allergy (Acetaminophen + Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Decongestant Antihistaminic Syrup (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dilotab (Acetaminophen + Phenylpropanolamine Hydrochloride) Dimetane Expectorant Liq (Brompheniramine Maleate + Guaifenesin + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetane Expectorant-C Syr (Brompheniramine Maleate + Codeine Phosphate + Guaifenesin + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetane Expectorant-Dc Syr (Brompheniramine Maleate + Guaifenesin + Hydrocodone Bitartrate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp Chewable Tablets (Brompheniramine Maleate + Phenylpropanolamine Hydrochloride) Dimetapp Children's Cold & Allergy Tablets (Brompheniramine Maleate + Phenylpropanolamine Hydrochloride) Dimetapp Children's Cold & Fever (Acetaminophen + Brompheniramine Maleate + Phenylpropanolamine Hydrochloride) Dimetapp Clear (Brompheniramine Maleate + Phenylpropanolamine Hydrochloride) Dimetapp Cold & Sinus (Acetaminophen + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp Cough & Cold Liqui-Gels - Cap (Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylpropanolamine Hydrochloride) Dimetapp Cough, Cold & Flu (Acetaminophen + Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylpropanolamine Hydrochloride) Dimetapp DM Elixir (Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp DM Tab (Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp Elixir (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp Extentabs (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp Liqui-Gels Cap (Brompheniramine Maleate + Phenylpropanolamine Hydrochloride) Dimetapp Oral Infant Drops (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp Tab (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp-C Syr (Brompheniramine Maleate + Codeine Phosphate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dristan Capsules (Acetylsalicylic Acid + Caffeine + Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Emercidin D Tab (Acetaminophen + Caffeine + Diphenylpyraline Hydrochloride + Phenylpropanolamine Hydrochloride) Emertabs Tab (Acetaminophen + Caffeine + Phenylpropanolamine Hydrochloride) Entex La (Guaifenesin + Phenylpropanolamine Hydrochloride) Entex La Tablets Srt (Guaifenesin + Phenylpropanolamine Hydrochloride) Extra Strength Contac C - Src (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Oradrine 2 Tab (Acetaminophen + Caffeine + Diphenylpyraline Hydrochloride + Phenylpropanolamine Hydrochloride) Oradrine Tablets (Acetaminophen + Caffeine + Codeine Phosphate + Diphenylpyraline Hydrochloride + Phenylpropanolamine Hydrochloride) Oradrine-2 Tab (Acetaminophen + Caffeine + Diphenylpyraline Hydrochloride + Phenylpropanolamine Hydrochloride) Ornade Af Liquid (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Ornade Af Spansule Src (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Ornade DM 10 Liq (Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Phenylpropanolamine Hydrochloride) Ornade DM 15 Liq (Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Phenylpropanolamine Hydrochloride) Ornade DM 30 Liq (Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Phenylpropanolamine Hydrochloride) Ornade Expectorant Cough Formula (Chlorpheniramine Maleate + Guaifenesin + Phenylpropanolamine Hydrochloride) Ornade Liquid (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Ornade Spansule Src (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Pharmacol DM Syr (Dextromethorphan Hydrobromide + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate) Pharmetapp Elixir (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Pharminicol DM Syrup (Dextromethorphan Hydrobromide + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate) Sine Off Nd Extra Strength Caplet (Acetaminophen + Phenylpropanolamine Hydrochloride) Sine-Off Allergy Tab (Acetaminophen + Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Sine-Off N.D. Tab (Acetaminophen + Phenylpropanolamine Hydrochloride) Sine-Off N.D. Tablet (Acetaminophen + Phenylpropanolamine Hydrochloride) Sinutab Sa Tab (Acetaminophen + Phenylpropanolamine Hydrochloride + Phenyltoloxamine Citrate) Tantacol DM Syr (Dextromethorphan Hydrobromide + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate) Tantapp Elixir (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Tavist-D Tablets (Clemastine (Clemastine Hydrogen Fumarate) + Phenylpropanolamine Hydrochloride) Tri-Anamine Cold Syrup (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Tri-Anamine Expect Antihist Decong Syrup (Guaifenesin + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate) Triaminic Cold and Allergy Syrup (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Triaminic DM Daytime Syr (Dextromethorphan Hydrobromide + Guaifenesin + Phenylpropanolamine Hydrochloride) Triaminic Expectorant Dh Syrup (Guaifenesin + Hydrocodone Bitartrate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate) Triaminic Time Release Tab (Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate) Triaminicin Colds & Flu Caplets (Acetaminophen + Caffeine + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate) Trisulfaminic Sus (Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate + Sulfadiazine + Sulfamerazine + Sulfamethazine) Trisulfaminic Tab (Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate + Sulfadiazine + Sulfamerazine + Sulfamethazine) Tussaminic C Forte Syrup (Codeine Phosphate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate) Tussaminic C Pediatric Syrup (Codeine Phosphate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate) Tussaminic Dh Forte Syrup (Hydrocodone Bitartrate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate) Tussaminic DH Pediatric Syrup (Hydrocodone Bitartrate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate)
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Formule chimique
C9H13NO
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RX lien
No information avaliable
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FDA fiche
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msds (fiche de securite des materiaux)
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Synthese de reference
Vanderbitle, Hass, Ind. Chem. 32, 34 (1940)
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Poids moleculaire
151.206 g/mol
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Point de fusion
190-194 oC
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H2O Solubilite
Librement soluble
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Etat
Solid
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LogP
0.974
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Formes pharmaceutiques
Tablet; Injection; Sirop
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Indication
Pour le traitement de la congestion nasale, le contrôle de l'incontinence urinaire, priapisme et l'obésité.
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Pharmacologie
Phénylpropanolamine (PPA), un agent sympathomimétique structurellement similaire à la pseudoéphédrine, est utilisé pour traiter la congestion nasale. Phénylpropanolamine se trouve dans les formulations de coupe-faim et avec guaifenesinin de toux froide formulations. En 2000, la FDA a demandé que toutes les compagnies pharmaceutiques arrêter la commercialisation de produits contenant de la phénylpropanolamine, due à une augmentation du risque d'AVC hémorragique chez les femmes qui ont utilisé la phénylpropanolamine.
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Absorption
Biodisponibilité réduite (environ 38%) à partir du tractus gastro-intestinal, car le métabolisme de premier passage par la monoamine oxydase dans l'estomac et le foie.
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Toxicite
Peut provoquer des extrasystoles ventriculaires et des paroxysmes court de tachycardie ventriculaire, une sensation de plénitude dans la tête et des fourmillements des extrémités; DL50 = 1490mg/kg (voie orale chez le rat)
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Information pour les patients
PATIENT INFORMATION
Description
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This medicine is used to treat nasal congestion caused by colds or hay fever. Your doctor may prescribe this medicine for
other conditions as well.
General Information
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This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in
this database. If you have questions about your medicines, talk to your healthcare provider.
Proper use of this medicine
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For proper use of this medicine, follow the directions on the package, unless otherwise instructed by your doctor. To use
a nose spray: gently blow your nose. Then sit back and tilt your head back slightly. Place the tip of the spray container
into the nose. Close off the other nostril with your other hand. Spray into the nose. Wait at least one minute in between
sprays. After using, rinse the tip of the sprayer in hot water and dry. This prevents contamination.
Missed Dose
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Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your
regular schedule. Do not double doses.
Storage
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Follow package directions for proper storage. Keep away from heat, moisture or light.
Possible Side Effects
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Some common side effects reported with this medicine include:
stinging
burning
sneezing
increase in nasal discharge
If you experience other bothersome side effects, talk to your health care provider.
Some common side effects with this medicine include:
burning or stinging inside your nose
confusion
nervousness
headache
nausea
vomiting
Report any of the following to your doctor:
dizziness
or fainting spells
difficulty breathing
chest pain
rapid heart beat
increased sweating
tingling or numbness in the hands or feet
Warnings/Precautions
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Do NOT use more that the recommended dose of this medicine.
Do NOT use more of this medicine or longer than prescribed.
Using this medicine longer that 3-5 days can cause a condition known as "rebound congestion".
Overdose
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Seek medical attention immediately. For non emergencies, contact your local or regional poison control center
Drug Interactions
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This medicine can cause in increase in toxic effects to the heart when taken with other stimulants. Avoid taking with:
theophylline
digoxin
general anesthetics
atropine
MAO inhibitors.
Taking this medicine with the following herbs can cause increased side effects including high blood pressure and should be
avoided:
ephedra
yohimbe
This medicine can interact with the following drugs:
atropine
bromocriptine
diuretics (water pills)
linezolid
maprotiline
drugs used for depression
high blood pressure medications
drugs used for migraine headaches
oxytocin
vasopressin
For more information on specific drug interactions, talk to your doctor or pharmacist.
Pregnancy/Nursing
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Talk to your doctor about using this medicine during pregnancy or nursing to discuss any possible risks to you or your baby.
More Information
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For more information about this medicine, talk to your healthcare provider.
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Organismes affectes
Les humains et autres mammifères