Categoria
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Nombres de marca,
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Analogos
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Agro Blue (Chlorhexidine Acetate + Glycerine) Avagard Chg (Alcohol Anhydrous + Chlorhexidine Gluconate) Baxedin 2% - 70% (Chlorhexidine Gluconate + Isopropyl Alcohol) Bio Text - Liq Hos (Alcohol Anhydrous + Chlorhexidine Gluconate) Biomers - Liq Ins (Alcohol Anhydrous + Chlorhexidine Gluconate) Bioprep (Chlorhexidine Gluconate + Didecyl Dimethyl Ammonium Chloride) Bioprep Liq (Chlorhexidine Gluconate + Didecyl Dimethyl Ammonium Chloride + Isopropyl Alcohol) Biosurf - Liq Hos (Alcohol Anhydrous + Chlorhexidine Gluconate) Boston Advance Comfort Formula Conditioning Solution (Chlorhexidine Gluconate + Disodium Edetate + Polyaminopropyl Biguanide) Boston Conditioning Solution (Chlorhexidine Gluconate + Disodium Edetate) Boston Simplicity Solution - Liquid (Chlorhexidine Gluconate + Edetic Acid + Polyaminopropyl Biguanide) Boston Simplus Multi-Action Solution (Chlorhexidine Gluconate + Polyaminopropyl Biguanide) Boston?Md Conditioning Solution (Chlorhexidine Gluconate + Disodium Edetate) Burn O Sol Spray (Benzocaine + Chlorhexidine Acetate) Centaur Light Lube Gel (Chlorhexidine + Ethyl Cellulose) Chloraprep Liq 0.5% (Chlorhexidine Gluconate + Isopropyl Alcohol) Chlorhexidine 0.5% Liq (Chlorhexidine Gluconate + Isopropyl Alcohol) Chlorhexidine and Isopropyl Alcohol Prep Pads (Chlorhexidine Gluconate + Isopropyl Alcohol) Chlorhexidine and Isopropyl Alcohol Swabsticks (Chlorhexidine Gluconate + Isopropyl Alcohol) Chlorhexidine-Cetrimide Soltn Conc (Cetrimonium Bromide + Chlorhexidine Gluconate) Cida-Stat Foam (Chlorhexidine Gluconate + Isopropyl Alcohol) Cida-Stat Liq (Chlorhexidine Gluconate + Isopropyl Alcohol) Comfortcare Wetting and Soaking Solution (Chlorhexidine Gluconate + Disodium Edetate) Della-Blue Teat Dip Non-Iodine (Chlorhexidine Acetate + Glycerine) Dexidin 0.5 Solution (Chlorhexidine Gluconate + Isopropyl Alcohol) Eye and Wound Powder (Chlorhexidine Hydrochloride + Hydrocortisone Acetate + Penicillin G Procaine + Sulfathiazole) Flamazine C (Chlorhexidine Gluconate + Silver Sulfadiazine) Foam Care Chg Surgical Hand Scrub (Chlorhexidine Gluconate + Isopropyl Alcohol) G2 (Alcohol Anhydrous + Chlorhexidine Gluconate) Germi-Stat Prep Gel (Chlorhexidine Gluconate + Isopropyl Alcohol) Hexifoam-Skin Disinfectant Aer 1% (Alcohol Anhydrous + Chlorhexidine Gluconate) Hibistat Germicidal Hand Rinse (Chlorhexidine Gluconate + Isopropyl Alcohol) Hx Dip (Post Milking Teat Dip) (Chlorhexidine Acetate + Glycerine) Hx Dip Lv (Post Milking Teat Dip) (Chlorhexidine Acetate + Glycerine) Ic-Gel (Chlorhexidine Gluconate + Isopropyl Alcohol) Inhibidex (Chlorhexidine Acetate + Glycerine) Lines (Alcohol Anhydrous + Chlorhexidine Gluconate) Mediwipe Pad (Chlorhexidine Gluconate + Phenoxyethanol) Ready Wipe (Alcohol Anhydrous + Chlorhexidine Acetate) Roby F60 Chlorhexidine Teat Dip (Chlorhexidine Acetate + Glycerine) Salvesept Crm (Cetrimonium Bromide + Chlorhexidine Gluconate) Sanhexidine Liq (Chlorhexidine Acetate + Glycerine + Lanolin) Sanidip (Chlorhexidine Acetate + Glycerine) Sanifilm (Chlorhexidine Acetate + Glycerine) Savlodil (Single Use) (Cetrimide + Chlorhexidine Gluconate) Savlon Hospital Concentrate (Cetrimide + Chlorhexidine Gluconate) Savlon Hospital Concentrate Disinf Liq (Cetrimonium Bromide + Chlorhexidine Gluconate) Scrub-Stat Iv 4% (Chlorhexidine Gluconate + Isopropyl Alcohol) Septefx (18.5%) (Alcohol Anhydrous + Chlorhexidine Gluconate + Edetic Acid) Septefx (70.5%) (Alcohol Anhydrous + Chlorhexidine Gluconate + Edetic Acid) Septi-San (Chlorhexidine Gluconate + Didecyl Dimethyl Ammonium Chloride) Soft Care Antiseptic Hand Soap (Chlorhexidine Gluconate + Didecyl Dimethyl Ammonium Chloride) Solu-I.V. Chg-Alcohol (Chlorhexidine Gluconate + Isopropyl Alcohol) Solu-I.V. Tiges Montees Chd Alcool - Stk (Chlorhexidine Gluconate + Isopropyl Alcohol) Solu-Iv Chd-Alcool Tampon (Chlorhexidine Gluconate + Isopropyl Alcohol) Soluprep Chd-Alcohol-Spg-Liq (Chlorhexidine Gluconate + Isopropyl Alcohol) Spectro Tar Antiseptic Shampoo (Chlorhexidine Gluconate + Coal Tar) Stanhexidine 2% with Isopropyl Alcohol 4% (Chlorhexidine Gluconate + Isopropyl Alcohol) Stanhexidine 4% with Isopropyl Alcohol 4% (Chlorhexidine Gluconate + Isopropyl Alcohol) Stanhexidine Aqueous 2% with 4% Isopropyl Alcohol (Chlorhexidine Gluconate + Isopropyl Alcohol) Stanhexidine Untinted Tincture 0.5% W Alco (Chlorhexidine Gluconate + Isopropyl Alcohol) Steri-Stat Liq 4.0% (Chlorhexidine Gluconate + Isopropyl Alcohol) Steri-Stat Tincture (Tinted) Antis Prep Gel (Chlorhexidine Gluconate + Isopropyl Alcohol) Sterigel (Alcohol Anhydrous + Chlorhexidine Gluconate) Stomadhex C-100 (Chlorhexidine Acetate + Nicotinamide) Stomadhex C-300 (Chlorhexidine Acetate + Nicotinamide) Swiffer Wetjet Antibacterial Floor Cleaner (Chlorhexidine Acetate + Didecyl Dimethyl Ammonium Chloride) Ultra Dip (Chlorhexidine Acetate + Glycerine) Ultra Dip Ext (Chlorhexidine Acetate + Glycerine) Ultra Dip LV (Chlorhexidine Acetate + Glycerine) Ultrastat (Chlorhexidine Hydrochloride + Sodium Alginate)
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Formula quimica
C22H30Cl2N10
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RX enlace
http://www.rxlist.com/cgi/generic2/chlorhexidine.htm
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FDA hoja
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MSDS (hoja de seguridad de materiales)
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Sintesis de referencia
Rose, Swain, J. Chem. Soc. 1956, 4422, EE.UU. Pat. 2,684,924 (1954)
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Peso molecular
505.446 g/mol
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Punto de fusion
134 oC
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H2O Solubilidad
0,08% (w / v)
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Estado
Solid
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LogP
4.066
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Formas de dosificacion
Enjuague bucal, Pellet (de liberación prolongada); Periochip (en una matriz biodegradable de los hidrolizados de gelatina entrecruzada con glutaraldehído), crema, aderezo, Gel, Loción, Ungüento; Esponja
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Indicacion
Para la reducción de la profundidad de la bolsa en los pacientes con periodontitis del adulto, que se utiliza como un complemento a la ampliación y los procedimientos de alisado radicular. También para la prevención de la caries dental, la descontaminación orofaríngea en estado crítico pacientes enfermos, la higiene de manos en el personal sanitario, limpieza de la piel en general, y la preparación del catéter y la atención.
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Farmacologia
Clorhexidina, un agente antimicrobiano tópico, es bactericida. Debido a su carga positiva, la molécula de clorhexidina reacciona con la superficie de las células microbianas para destruir la integridad de la membrana celular. . Este novedoso mecanismo de acción hace que sea muy poco probable para el desarrollo de resistencia bacteriana.
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Absorcion
La absorción de la clorhexidina en el tracto gastrointestinal es muy pobre. Además, un estudio in vivo en 18 pacientes adultos no encontró detectable en plasma o la orina concentraciones de clorhexidina después de la inserción de cuatro implantes periodontal bajo condiciones clínicas.
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Toxicidad
LD50 = 2g/kg (humanos, oral); LD50 = 3 g / kg (rata, oral); LD50 = 2,5 g / kg (ratones, por vía oral); DL50 = 21 mg / kg (rata macho, IV); LD50 = 23 mg / kg (rata hembra, IV); DL50 = 25 mg / kg (ratones machos, IV); DL50 = 24 mg / kg (hembra ratones, IV); LD50 = 1g/kg (rata, por vía subcutánea), LD50 = 637 mg / kg (ratones machos, subcutánea), LD50 = 632 mg / kg (ratones hembras, subcutánea)
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Informacion de Pacientes
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Organismos afectados
Las bacterias
