Sotis

• Anticholesteremic Agents
• HMG-CoA Reductase Inhibitors
• ATC:C10AA05

• Atorvastatin calcium
• Atorvastatin calcium salt
• Atorvastatin, Calcium salt
• Cardyl
• Lipitor
• Sotis
• Torvast
• Tozalip
• Xavator

No information avaliable

C₃₃H₃₅FN₂O₅

http://www.rxlist.com/cgi/generic/atorvastatin.htm

Sotis FDA

Sotis MSDS

BD Roth, EE.UU. Pat. 5273, 995 (1991, 1993)

558.64 g/mol

159.2-160.7^oC

Sodio soluble en agua salada, el 20,4 ug / ml (pH 2,1), 1,23 mg / ml (pH 6,0)

Solid

6.259

Comprimido (10 mg, 20 mg o 40 mg)

Para la gestión como un complemento a la dieta para reducir los niveles de C-total, LDL-C, apo B, y los niveles de TG en pacientes con hipercolesterolemia primaria y dislipidemia mixta.

Atorvastatina, un selectivo y competitivo de la HMG-CoA reductasa, se utiliza para reducir el colesterol y los triglicéridos en pacientes con hipercolesterolemia y dislipidemia mixta y en el tratamiento de homocigotos hipercolesterolemia familiar. Atorvastatina tiene una estructura única, larga vida media, y la selectividad hepática, que explica su mayor potencia de disminución de LDL en comparación con otros inhibidores de la HMG-CoA reductasa.

La atorvastatina se absorbe rápidamente tras la administración oral. La biodisponibilidad absoluta de atorvastatina (droga madre) es de aproximadamente 14% y la disponibilidad sistémica de inhibidores de la HMG-CoA reductasa actividad inhibitoria es de aproximadamente 30%.

Rabdomiolisis, hemorragias oculares, y problemas hepáticos.

Lipitor is a HMG-CoA Reductase Inhibitor, also known as a statin. This class
of treatments for high cholesterol is fairly new, and appears to work by
blocking a liver enzyme which generates cholesterol. This medication appears
to be the most effective in this class of drugs at lowering unhealthy LDL
(low-density lipoprotein) cholesterol levels, in some cases up to 51%. It
can be virtually as effective as an angioplasty in treating stable coronary
artery disease. Currently, this drug is approved for use in patients with
high cholesterol (hypercholesterolemia) due to high LDL levels, hereditary
elevated fat levels (dysbetalipoproteinemia), familial high cholesterol,
and to increase HDL (high-density lipoprotein) levels in patients with high
cholesterol and those with both high cholesterol and high triglycerides (mixed
dyslipidemia). Other accepted uses include the treatment of stable coronary
artery diseas, preventing coronary heart disease, preventing clogged stents
(tubes) placed in coronary arteries after surgery, preventing bone loss in
type two diabetics, stabilizing lipid levels that have been altered by treatment
with protease inhibitors. This treatment should be considered a last resort.
The best way to lower cholesterol is through a program of healthy diet and
exercise, and these should be maintained during treatment with Lipitor.

Humanos y otros mamíferos