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  • NF Formula quimica

    C32H45N3O4S

    NF RX enlace

    http://www.rxlist.com/cgi/generic2/nelfin.htm

    NF FDA hoja

    NF FDA

    NF MSDS (hoja de seguridad de materiales)

    NF MSDS

    NF Sintesis de referencia

    No hay información disponible

    NF Peso molecular

    567.784 g/mol

    NF Punto de fusion

    349.84 oC

    NF H2O Solubilidad

    Ligeramente soluble

    NF Estado

    Solid

    NF LogP

    5.247

    NF Formas de dosificacion

    Tablet (oral - 250 mg, 625 mg) en polvo (oral)

    NF Indicacion

    NF Farmacologia

    Nelfinavir es un inhibidor de la proteasa con actividad contra el virus de inmunodeficiencia humana tipo 1 (VIH-1). Inhibidores de la proteasa bloquean la parte del VIH llamada proteasa. VIH-1 proteasa es una enzima necesaria para la enzima. Esta inhibición impide la división de las poliproteínas viral que resulta en la formación de inmaduros no partículas virales infecciosas. Inhibidores de la proteasa se utilizan casi siempre en combinación

    NF Absorcion

    Se absorbe bien tras la administración oral.

    NF Toxicidad

    DL50 oral es más 5g/kg en ratas. Los efectos secundarios incluyen la sed y el hambre, la pérdida de peso inexplicable, aumento de la orina, fatiga, piel seca, picazón.

    NF Informacion de Pacientes

    PATIENT INFORMATION

    Patients should be informed that VIRACEPT is not a cure for HIV infection and that they may
    continue to acquire illnesses associated with advanced HIV infection, including opportunistic
    infections.

    Patients should be told that the long-term effects of VIRACEPT are unknown at this time. They
    should be told that there is currently no data demonstrating that VIRACEPT therapy can reduce
    the risk of transmitting HIV to others through sexual contact or blood contamination.

    Patients should be advised to take VIRACEPT every day as prescribed. Patients should not alter
    the dose or discontinue therapy without consulting with their doctor. If a dose is missed, patients
    should take the dose as soon as possible and then return to their normal schedule. However, if a dose
    is skipped, the patient should not double the next dose.

    The most frequent adverse event associated with VIRACEPT is diarrhea, which can usually be controlled
    with non-prescription drugs, such as loperamide, which slow gastrointestinal motility.

    VIRACEPT may interact with some drugs, therefore, patients should be advised to report to their doctor
    the use of any other prescription or non-prescription medication.

    Patients receiving oral contraceptives should be instructed that alternate or additional contraceptive
    measures should be used during therapy with VIRACEPT.

    NF Organismos afectados

    Virus de inmunodeficiencia humana