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Nombres de marca,
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Analogos
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Alka Seltzer Plus Cold Medicine Evt (Acetylsalicylic Acid + Chlorpheniramine Maleate + Phenylpropanolamine Bitartrate) Alka-Seltzer Plus Cold Medicine - Evt (Acetylsalicylic Acid + Chlorpheniramine Maleate + Phenylpropanolamine Bitartrate) Allergy Sinus Medication - Caplet (Acetaminophen + Chlorpheniramine Maleate + Pseudoephedrine Hydrochloride) Ana-Kit (2mg/Tab Orl, 1mg/Ml Liq Sc Im) (Chlorpheniramine Maleate + Epinephrine) Ana-Kit (Chlorpheniramine Maleate + Epinephrine Hcl) Anakit Insect Sting Treatment Kit (Chlorpheniramine Maleate + Epinephrine) Bronchodex D Cap (Chlorpheniramine Maleate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride) Children's Tylenol Cold Chewable Tablets (Acetaminophen + Chlorpheniramine Maleate + Pseudoephedrine Hydrochloride) Children's Tylenol Cold Liquid (Acetaminophen + Chlorpheniramine Maleate + Pseudoephedrine Hydrochloride) Children's Tylenol Cold Liquid with Dm (Acetaminophen + Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride) Chlor Tripolon Decongest Syr (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Cold Decongestant Long Acting Cap (Chlorpheniramine Maleate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride) Coltalin Tablet (Acetaminophen + Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Contac Cold Capsules (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Contac Cold Extra Strength Capsules (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Contac Cough Cold and Flu Caplets (Acetaminophen + Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Phenylpropanolamine Hydrochloride) Contact C Src (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Coricidin D Long Acting Tab (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Coricidin D Tab (Acetylsalicylic Acid + Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Coricidin Sinus Headache Tab (Acetaminophen + Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Coricidin Tab (Acetylsalicylic Acid + Chlorpheniramine Maleate) Corsym Suspension (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Counteract Sinus and Allergy (Acetaminophen + Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Dristan Capsules (Acetylsalicylic Acid + Caffeine + Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Extra Strength Allergy Plus Sinus Relief (Acetaminophen + Chlorpheniramine Maleate + Pseudoephedrine Hydrochloride) Extra Strength Allergy Sinus Medication (Acetaminophen + Chlorpheniramine Maleate + Pseudoephedrine Hydrochloride) Extra Strength Contac C - Src (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Extra Strength Nighttime Cold Relief-Caplet (Acetaminophen + Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride) Extra Strength Tylenol Cold and Flu Powder (Acetaminophen + Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride) Extra Strength Tylenol Cold Nighttime Caplet (Acetaminophen + Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride) Extra Strength Tylenol Sinus Nighttime (Acetaminophen + Chlorpheniramine Maleate + Pseudoephedrine Hydrochloride) Grippalin & C Tab (Acetaminophen + Chlorpheniramine Maleate + Vitamin C) Neocitran Total (Acetaminophen + Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride) Omni-Tuss Sus (Chlorpheniramine + Codeine + Ephedrine As Resin Complex + Guaiacol Carbonate + Phenyltoloxamine) Once-a-Day Benylin Cold Cap (Chlorpheniramine Maleate + Pseudoephedrine Hydrochloride) Ornade Af Liquid (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Ornade Af Spansule Src (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Ornade Dm 10 Liq (Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Phenylpropanolamine Hydrochloride) Ornade Dm 15 Liq (Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Phenylpropanolamine Hydrochloride) Ornade Dm 30 Liq (Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Phenylpropanolamine Hydrochloride) Ornade Expectorant Cough Formula (Chlorpheniramine Maleate + Guaifenesin + Phenylpropanolamine Hydrochloride) Ornade Liquid (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Ornade Spansule Src (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Pendamine (Chlorpheniramine Maleate + Dexamethasone + Dihydrostreptomycin Sulfate + Penicillin G Procaine) Pentuss Srs (Chlorpheniramine Maleate + Codeine) Reg.Str.Cold Medic.(Night Time Relief)Caplet (Acetaminophen + Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride) Regular Strength Tylenol Cold and Flu Powder (Acetaminophen + Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride) Regular Strength Tylenol Cold Nighttime Caplet (Acetaminophen + Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride) Sine-Off Allergy Tab (Acetaminophen + Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Theraflu Flu Cold and Cough Medicine (Acetaminophen + Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride) Tri-Anamine Cold Syrup (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Triaminic Cold and Allergy Syrup (Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride) Triaminic Dm Expectorant Syr (Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride) Triaminic Expectorant Syr (Chlorpheniramine Maleate + Guaifenesin + Pseudoephedrine Hydrochloride) Triaminicol Dm Syrup (Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
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Formula quimica
C16H19ClN2
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RX enlace
http://www.rxlist.com/cgi/generic3/chlorpheniramine.htm
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FDA hoja
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MSDS (hoja de seguridad de materiales)
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Sintesis de referencia
No hay información disponible
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Peso molecular
274.788 g/mol
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Punto de fusion
142 oC (boiling point)
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H2O Solubilidad
5,5 g / L
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Estado
Liquid
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LogP
3.563
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Formas de dosificacion
Líquido, jarabe, Tablet, Tablet (de liberación prolongada)
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Indicacion
Para el tratamiento de la rinitis, urticaria, alergia, resfriado común, asma y fiebre del heno.
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Farmacologia
En las reacciones alérgicas de un alergeno interactúa con enlaces cruzados y la superficie de anticuerpos IgE en los mastocitos y basófilos. Una vez que los mastocitos antígeno-anticuerpo complejo está formado, de una compleja serie de acontecimientos que finalmente conduce a la degranulación de células y la liberación de histamina (y otros mediadores químicos) de los mastocitos o basófilos. Una vez liberada, la histamina puede reaccionar con los tejidos locales o generalizadas a través de los receptores de histamina. Histamina, que actúa en los receptores H1, produce prurito, vasodilatación, hipotensión, enrojecimiento, dolor de cabeza, taquicardia y broncoconstricción. La histamina también aumenta vascular la permeabilidad y la potencia del dolor. Clorfeniramina, es un antagonista de la histamina H1 (o más correctamente, un agonista de la histamina inversa) de la clase alquilamina. Compite con la histamina para el normal H1- sitios receptores en las células efectoras del tubo digestivo, los vasos sanguíneos y las vías respiratorias. Se proporciona un alivio eficaz y temporal de los estornudos, ojos llorosos y picazón y secreción nasal, debido a heno fiebre y otras alergias respiratorias superiores.
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Absorcion
Se absorbe bien en el tracto gastrointestinal.
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Toxicidad
LD50 = 306 mg / kg en los seres humanos, la toxina leve reproductiva a las mujeres en edad fértil.
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Informacion de Pacientes
May cause excitability especially in children. Do not take this
product unless directed by a physician, if you have a breathing problem such as emphysema or chronic bronchitis, or
if you have glaucoma or difficulty in urination due to enlargement of the prostate gland. May cause drowsiness;
alcohol, sedatives and tranquilizers may increase the drowsiness effect. Avoid alcoholic beverages, and do not take
this product if you are taking sedatives or tranquilizers without first consulting your physician. Use caution when
driving a motor vehicle or operating machinery.
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Organismos afectados
Humanos y otros mamíferos
