Dantrium

• Muscle Relaxants, Central
• ATC:M03CA01

• Dantrium
• Dantrium Intravenous
• Dantrolene Sodium
• Dantrolene [USAN:BAN:INN]
• Dantroleno [INN-Spanish]
• Dantrolenum [INN-Latin]

Acti Poultice (Eucalyptus Oil + Magnesium Sulfate + Menthol + Methyl Salicylate + Thymol)

Agobyl Granule (Magnesium Sulfate + Peptone)

Agobyl Liquide (Magnesium Sulfate + Peptone)

Alsilax (Boldo + Cascara Sagrada + Magnesium Sulfate + Pancreatin + Peptone)

Amino Acid Concentrate Inj (Arginine Hcl + Calcium Chloride + Dexpanthenol + Dextrose + Dl-Methionine + Glutamic Acid + Histidine Hcl + Isoleucine + L-Cysteine Hydrochloride + L-Lysine Hydrochloride + Leucine + Magnesium Sulfate + Nicotinamide + Phenylalanine + Potassium Chloride + Sodium Acetate + Threonine + Tryptophan + Valine + Vitamin B1 (Thiamine) + Vitamin B12 + Vitamin B2 (Riboflavin) + Vitamin B6 (Pyridoxine))

Amino Acid Formula Inj (Alanine + Arginine + Calcium Chloride + Calcium D-Pantothenate + Dextrose + Dl-Methionine + Glutamic Acid + Glycine + Histidine + Isoleucine + L-Aspartic Acid + Leucine + Lysine + Magnesium Sulfate + Nicotinamide + Phenylalanine + Potassium Chloride + Proline + Pyridoxine Hydrochloride + Riboflavin 5'-Phosphate Sodium + Serine + Sodium Acetate + Sodium Glutamate + Thiamine Hydrochloride + Threonine + Tryptophan + Tyrosine + Valine + Vitamin B12)

Amino Acid Formula Inj (Alanine + Arginine + Calcium Chloride + Calcium D-Pantothenate + Dextrose + Glutamic Acid + Glycine + Histidine + Isoleucine + L-Aspartic Acid + Leucine + Lysine + Magnesium Sulfate + Methionine + Nicotinamide + Phenylalanine + Potassium Chloride + Proline + Pyridoxine Hydrochloride + Riboflavin-5-Phosphate + Serine + Sodium Acetate + Sodium Glutamate + Thiamine Hydrochloride + Threonine + Tryptophan + Tyrosine + Valine + Vitamin B12)

Amino Acid Inj (Arginine + Calcium Chloride + D-Pantothenic Acid (Calcium D-Pantothenate) + Dextrose + Histidine + Isoleucine + L-Cysteine Hydrochloride + Leucine + Lysine + Magnesium Sulfate + Methionine + Nicotinamide + Phenylalanine + Potassium Chloride + Pyridoxine Hydrochloride + Sodium Acetate + Threonine + Tryptophan + Valine + Vitamin B1 + Vitamin B12 + Vitamin B2)

Amino Lite (Arginine + Calcium Chloride + Dextrose + Isoleucine + L-Cysteine Hydrochloride + L-Histidine Hcl + L-Lysine Hydrochloride + Leucine + Magnesium Sulfate + Methionine + Nicotinic Acid + Phenylalanine + Potassium Chloride + Pyridoxine Hydrochloride + Sodium Glutamate + Thiamine Hydrochloride + Threonine + Tryptophan + Valine + Vitamin B12 + Vitamin B2 (Riboflavin 5'-Phosphate Sodium))

Amino Solution - Liq (Calcium Chloride + Calcium D-Pantothenate + Casein Hydrolysate + Dextrose + Magnesium Sulfate + Nicotinamide + Pyridoxine Hydrochloride + Sodium Acetate + Vitamin B1 (Acetiamine) + Vitamin B12 + Vitamin B2)

Amino Solution Inj (Arginine + Calcium Chloride + Calcium D-Pantothenate + Dextrose + Dl-Methionine + Histidine + Isoleucine + Leucine + Lysine + Magnesium Sulfate + Nicotinamide + Phenylalanine + Sodium Acetate + Threonine + Tryptophan + Valine + Vitamin B1 + Vitamin B12 + Vitamin B2 + Vitamin B6)

Anticoryzax (Calcium Lactophosphate + Magnesium Sulfate + Ribonucleic Acid + Vitamin C)

Bvs Amino Acid Solution Inj (Arginine Hcl + Calcium Chloride + Dexpanthenol + Dextrose + Dl-Isoleucine + L-Cysteine Hydrochloride + L-Histidine Hcl + L-Lysine Hydrochloride + Leucine + Magnesium Sulfate + Methionine + Nicotinamide + Phenylalanine + Potassium Chloride + Pyridoxine Hydrochloride + Sodium Acetate Hemodialysis + Sodium Glutamate + Threonine + Tryptophan + Valine + Vitamin B1 + Vitamin B12 + Vitamin B2)

Bylium Liq (Boldo + Cascara Sagrada + Magnesium Sulfate + Pancreatin + Peptone)

Calcium Lactate Et Magnesium Sulfate (Calcium Lactate + Magnesium Sulfate)

Calcium/Magnesium Drink (Calcium (Calcium Lactate, Calcium Carbonate, Calcium Glycerophosphate) + Magnesium (Magnesium Citrate, Magnesium Sulfate, Magnesium Oxide))

Calf Electrolytes (Calcium Lactate + Ferrous Sulfate + Magnesium Sulfate + Potassium Chloride + Sodium Chloride + Vitamin a + Vitamin B12)

Calf-Lyte (Calcium Chloride + Calcium D-Pantothenate + Dextrose + Glycine + Magnesium Sulfate + Potassium Chloride + Potassium Citrate + Potassium Phosphate Monobasic + Sodium Chloride + Sodium Phosphate Monobasic + Vitamin C)

Disc-Discovery Tablets (Calcium (Calcium Phosphate (Dibasic), Calcium Ascorbate) + Magnesium (Magnesium Sulfate, Magnesium Oxide) + Manganese (Manganese Sulfate) + Potassium (Potassium Citrate) + Vitamin B6 (Pyridoxine Hydrochloride) + Vitamin C (Ascorbic Acid, Calcium Ascorbate) + Vitamin D3 (Cholecalciferol) + Zinc Sulfate)

Eau Purgative Riga (Magnesium Sulfate + Sodium Sulfate)

Electrosul (Calcium Chloride + Calcium D-Pantothenate + Cobalt Sulfate + Copper Sulfate + Ferrous Sulfate + Magnesium Sulfate + Manganese Sulfate + Nicotinic Acid + Potassium Chloride + Sodium Chloride + Sulfamerazine Sodium + Sulfathiazole Sodium + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D3 + Zinc Sulfate)

Flex Capsules (Calcium (Calcium Ascorbate) + Magnesium Sulfate + Potassium (Potassium Sulfate))

Formule 1705 - Liq (Magnesium Sulfate + Ox Bile Extract)

Ion Aid (Calcium Gluconate + Dextrose + Glycine + Magnesium Sulfate + Potassium Phosphate Monobasic + Sodium Chloride)

Laxabyl No109 (Barberry Root + Boldo + Cascara Sagrada + Magnesium Sulfate + Pancreatin + Peptone + Taraxacum Officinale Weber)

Life Guard H E Pws (Calcium Phosphate (Dibasic) + Dextrose + Glycine + Magnesium Sulfate + Potassium Chloride + Sodium Bicarbonate + Sodium Chloride)

Life Guard Oral (Calcium Phosphate (Dibasic) + Dextrose + Glycine + Magnesium Sulfate + Potassium Chloride + Protein + Sodium Bicarbonate + Sodium Chloride)

Life Guard Pws Twin-Pak (Calcium Phosphate + Dextrose + Glycine + Magnesium Sulfate + Potassium Chloride + Protein + Sodium Bicarbonate + Sodium Chloride)

Life-Guard H.E. Pwr (Calcium Phosphate + Dextrose + Glycine + Magnesium Sulfate + Potassium Chloride + Sodium Bicarbonate + Sodium Chloride)

Magnesium Cap (Magnesium Oxide + Magnesium Sulfate)

Magnesium Sulfate in 5%Dextrose Inj(20mg/Ml) (Dextrose + Magnesium Sulfate)

Medi-3-Sulvita (Calcium Chloride + D-Pantothenic Acid + Magnesium Sulfate + Nicotinamide + Potassium Chloride + Sodium Acetate + Sodium Chloride + Sulfamerazine Sodium + Sulfamethazine Sodium + Sulfathiazole Sodium + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D3)

Multi-Vi-Min Capsules (Biotin + Chromium (Chromium Hvp Chelate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Folic Acid + Iron (Ferric Ammonium Citrate) + Magnesium Sulfate + Manganese (Manganese Oxide) + Molybdenum (Sodium Molybdate) + Nicotinamide + Potassium (Potassium Chloride) + Selenium (Sodium Selenite) + Vitamin a (Vitamin a Palmitate) + Vitamin B1 (Thiamine Hydrochloride) + Vitamin B12 + Vitamin B2 (Riboflavin-5-Phosphate) + Vitamin B6 (Pyridoxal-5-Phosphate) + Vitamin B6 (Pyridoxine Hydrochloride) + Vitamin C + Vitamin E (Dl-Alpha Tocopheryl Acetate) + Zinc Sulfate)

Multiple Electrolyte Additive Inj (Calcium Gluconate + Magnesium Sulfate + Potassium Chloride + Sodium Chloride)

Multivitamins + Minerals - Tab (Biotin + Calcium D-Pantothenate + Calcium Phosphate (Dibasic) + Copper Sulfate + Dl-Alpha Tocopheryl Acetate + Ferrous Fumarate + Folic Acid + Magnesium Sulfate + Nicotinamide + Pyridoxine Hydrochloride + Thiamine Mononitrate + Vitamin a Palmitate + Vitamin B12 + Vitamin B2 + Vitamin C + Vitamin D3)

Multivitamins and Minerals (Biotin + Calcium (Calcium Phosphate) + Copper (Copper Sulfate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Folic Acid + Iron + Magnesium Sulfate + Nicotinamide + Phosphorus (Calcium Phosphate) + Vitamin a (Vitamin a Palmitate) + Vitamin B1 (Thiamine Mononitrate) + Vitamin B12 + Vitamin B2 + Vitamin B6 (Pyridoxine Hydrochloride) + Vitamin C + Vitamin D + Vitamin E (D-Alpha Tocopheryl Acetate))

Nutravit Pst (Calcium D-Pantothenate + Folic Acid + Iodine (Potassium Iodide) + Iron (Iron Peptonized) + Magnesium Sulfate + Manganese (Manganese Sulfate) + Nicotinamide + Pyridoxine Hydrochloride + Thiamine Hydrochloride + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D + Vitamin E)

Poulti-Paste (Glycerine + Magnesium Sulfate + Methyl Salicylate)

Poultice (Acetic Acid + Glycerine + Kaolin + Magnesium Sulfate + Menthol + Sodium Borate)

Poultice - Pst (Acetic Acid + Kaolin + Magnesium Sulfate + Sodium Borate)

Poultice Powder (Aluminum Potassium Sulfate + Bentonite + Magnesium Sulfate + Methyl Salicylate)

Pro-Laxol Liq (Boldo + Cascara Sagrada + Magnesium Sulfate)

Pro-Lyte (Calcium Chloride + Calcium D-Pantothenate + Dextrose + Glycine + Magnesium Sulfate + Potassium Chloride + Potassium Citrate + Potassium Phosphate Monobasic + Sodium Chloride + Sodium Phosphate Monobasic + Vitamin C)

Ratanhia Comp. Drops (Calcium Fluoride + Esculin + Krameria (Triandra) + Magnesium Sulfate + Myrrh + Olea Europea Homeo Chemical + Silver Nitrate)

Reducine Medicated Poultice Pst (Aluminum Ammonium Sulfate Dodecahydrate + Bentonite + Glycerine + Kaolin + Magnesium Sulfate + Methyl Salicylate + Peppermint Oil)

Scarlet Pwr (Calcium Phosphate + Ethylenediamine Dihydroiodide + Fenugreek + Gentiana Lutea + Ginger + Iron Oxide + Linum Usitatissimum + Magnesium Carbonate + Magnesium Sulfate + Sodium Sulfate + Sodium Thiosulfate)

Solution Carda (Magnesium Sulfate + Potassium Bicarbonate + Sodium Bicarbonate)

Stress (Calcium Phosphate + Cobalt Sulfate + Copper Sulfate + Ferrous Gluconate + Magnesium Sulfate + Manganese Sulfate + Potassium Iodide + Sodium Phosphate Monobasic + Vitamin a + Vitamin D3 + Zinc Sulfate)

Stv Amino Acid Sol Inj (Arginine Hcl + Calcium Chloride + Dexpanthenol + Dextrose + Dl-Methionine + Glutamic Acid + Histidine Hcl + Isoleucine + L-Cysteine Hydrochloride + L-Lysine Hydrochloride + Leucine + Magnesium Sulfate + Nicotinamide + Phenylalanine + Potassium Chloride + Pyridoxine Hydrochloride + Sodium Acetate + Threonine + Tryptophan + Valine + Vitamin B1 (Thiamine) + Vitamin B12 + Vitamin B2 (Riboflavin))

Super Multiple Vitamins and Min Tab (Biotin + Calcium (Calcium Phosphate) + Calcium D-Pantothenate + Copper (Copper Sulfate) + D-Alpha Tocopheryl Acetate + Folic Acid + Iron + Magnesium Sulfate + Nicotinamide + Phosphorus (Calcium Phosphate) + Vitamin a (Vitamin a Palmitate) + Vitamin B1 (Thiamine Mononitrate) + Vitamin B12 + Vitamin B2 + Vitamin B6 (Pyridoxine Hydrochloride) + Vitamin C + Vitamin D)

Tetra Fungistop (Magnesium Sulfate + Silver + Sodium Chloride)

C₁₄H₁₀N₄O₅

http://www.rxlist.com/cgi/generic3/dantrolene.htm

Dantrium MSDS

No hay información disponible

314.253 g/mol

279-280 ^oC

Bajas (146 mg / L)

Solid

1.506

Cápsula, polvo para solución

Para su uso, junto con las medidas de apoyo, para la gestión de la hipermetabolismo fulminante del músculo esquelético característico de las crisis de hipertermia maligna en pacientes de todas las edades. También utilizados antes de la operación y, a veces después de la cirugía, para prevenir o atenuar la aparición de signos clínicos y de laboratorio de la hipertermia maligna en individuos juzgados como hipertermia maligna susceptibles.

El dantroleno se clasifica como un relajante muscular de acción directa del esqueleto. Es actualmente el único tratamiento específico y eficaz para la hipertermia maligna. En aislada del nervio-músculo preparación, Dantrium Se ha demostrado que produce la relajación que afectan a la respuesta contráctil del músculo en un sitio más allá de la unión neuromuscular. En el músculo esquelético, Dantrium disocia acoplamiento excitación-contracción, probablemente al interferir con la liberación de Ca2 + del retículo sarcoplasmático. En el síndrome de hipertermia maligna inducida por anestésicos, la evidencia apunta a una anormalidad intrínseca del músculo esquelético tejidos. En los seres humanos seleccionados, se ha postulado que "agentes desencadenantes" (por ejemplo, los anestésicos generales y los agentes bloqueadores neuromusculares despolarizantes) producir un cambio dentro de la célula que resultados en un calcio mioplásmico elevada. Este calcio mioplásmico elevados activa aguda procesos catabólicos celulares que caen en cascada a la crisis de hipertermia maligna. La hipótesis es que además de de Dantrium a la "activa" de células malignas muscular hipertermia restablece un nivel normal de calcio ionizado en el myoplasm.

La biodisponibilidad es del 70%.

DL50 oral en ratas es de 7400 mg / kg. Los síntomas que pueden ocurrir en caso de sobredosis incluyen, pero no se limitan a, debilidad muscular y alteraciones en el estado de conciencia (por ejemplo, letargia, coma), vómitos, diarrea, y cristaluria.

Humanos y otros mamíferos