CCNU
Categoria
CCNU Nombres de marca, CCNU Analogos
CCNU Marca los nombres de mezcla
CCNU Formula quimica
C9H16ClN3O2
CCNU RX enlace
http://www.rxlist.com/cgi/generic2/lomustine.htm
CCNU FDA hoja
CCNU MSDS (hoja de seguridad de materiales)
CCNU Sintesis de referencia
Johnston, TP et al,. J.Med.Chem;. 9, 892-911 (1966)
CCNU Peso molecular
233.695 g/mol
CCNU Punto de fusion
88-90 oC
CCNU H2O Solubilidad
111 mg / L
CCNU Estado
Solid
CCNU LogP
2.629
CCNU Formas de dosificacion
Cápsulas (10 mg, 40 mg y 100 mg)
CCNU Indicacion
Indicado principalmente para el tratamiento de tumores cerebrales. También para el tratamiento del cáncer de mama, enfermedad de Hodgkin, cáncer de pulmón, melanoma maligno, mieloma múltiple, linfomas no-Hodgkin, cáncer de ovario, cáncer de páncreas y cáncer de células renales.
CCNU Farmacologia
Lomustina es un agente alquilante del tipo de nitrosourea. Lomustina y sus metabolitos interfieren con la función del ADN y el ARN. Es el ciclo celular de fase no específica. Cánceres se forman cuando algunas células dentro del cuerpo se multiplican sin control y anormal. Estas células luego se extendió y destruir los tejidos cercanos. Lomustina actúa reduciendo la velocidad de este proceso hacia abajo. Destruye las células cancerosas al dañar el ADN (la genética materiales dentro de las células) y se lo impide su multiplicación.
CCNU Absorcion
Bien y rápidamente absorbido desde el tracto gastrointestinal.
CCNU Toxicidad
Vía oral en rata: DL50 = 70 mg / kg. La toxicidad pulmonar se ha reportado con dosis acumulada generalmente superior a 1.100 mg/m2. Hay un informe de toxicidad pulmonar con una dosis acumulada de sólo 600 mg. La la aparición de toxicidad ha variado desde los 6 meses después del inicio de la terapia, a tan tarde como 15 años después.
CCNU Informacion de Pacientes
Lomustine (loe-MUS-teen) is a drug that is used to treat some kinds of cancer.
It is a capsule that you take by mouth.
A blood sample will be taken before each treatment. The dose and timing of your
chemotherapy may be changed based on your blood counts and/or other side effects.
It is important to take lomustine exactly as directed by your doctor. Make sure
you understand the directions. You may be given capsules of more than one strength
to make the right dose. Unless your doctor gives you other directions, take all
the capsules as a single dose at bedtime (on an empty stomach with a glass of water).
If you vomit within 45 minutes of taking lomustine, call your cancer doctor the
next morning.
Store lomustine capsules out of the reach of children, at room temperature, away
from heat, light and moisture.
Other drugs may interact with lomustine. Check with your doctor or pharmacist before
you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or usefulness
of lomustine.
Lomustine may cause sterility in men and menopause in women which may be permanent.
If you plan to have children, discuss this with your doctor before being treated with
lomustine.
Lomustine may damage sperm and may harm the baby if used during pregnancy. It is best
to use birth control while being treated with lomustine. Tell your doctor right away
if you or your partner becomes pregnant. Do not breast feed during treatment.
Tell doctors or dentists that you are taking lomustine before you receive any treatment
from them.
It is a capsule that you take by mouth.
A blood sample will be taken before each treatment. The dose and timing of your
chemotherapy may be changed based on your blood counts and/or other side effects.
It is important to take lomustine exactly as directed by your doctor. Make sure
you understand the directions. You may be given capsules of more than one strength
to make the right dose. Unless your doctor gives you other directions, take all
the capsules as a single dose at bedtime (on an empty stomach with a glass of water).
If you vomit within 45 minutes of taking lomustine, call your cancer doctor the
next morning.
Store lomustine capsules out of the reach of children, at room temperature, away
from heat, light and moisture.
Other drugs may interact with lomustine. Check with your doctor or pharmacist before
you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or usefulness
of lomustine.
Lomustine may cause sterility in men and menopause in women which may be permanent.
If you plan to have children, discuss this with your doctor before being treated with
lomustine.
Lomustine may damage sperm and may harm the baby if used during pregnancy. It is best
to use birth control while being treated with lomustine. Tell your doctor right away
if you or your partner becomes pregnant. Do not breast feed during treatment.
Tell doctors or dentists that you are taking lomustine before you receive any treatment
from them.
CCNU Organismos afectados
Humanos y otros mamíferos
