Atorvastatin
Categoria
Atorvastatin Nombres de marca, Atorvastatin Analogos
Atorvastatin Marca los nombres de mezcla
Atorvastatin Formula quimica
C33H35FN2O5
Atorvastatin RX enlace
http://www.rxlist.com/cgi/generic/atorvastatin.htm
Atorvastatin FDA hoja
Atorvastatin MSDS (hoja de seguridad de materiales)
Atorvastatin Sintesis de referencia
BD Roth, EE.UU. Pat. 5273, 995 (1991, 1993)
Atorvastatin Peso molecular
558.64 g/mol
Atorvastatin Punto de fusion
159.2-160.7oC
Atorvastatin H2O Solubilidad
Sodio soluble en agua salada, el 20,4 ug / ml (pH 2,1), 1,23 mg / ml (pH 6,0)
Atorvastatin Estado
Solid
Atorvastatin LogP
6.259
Atorvastatin Formas de dosificacion
Comprimido (10 mg, 20 mg o 40 mg)
Atorvastatin Indicacion
Para la gestión como un complemento a la dieta para reducir los niveles de C-total, LDL-C, apo B, y los niveles de TG en pacientes con hipercolesterolemia primaria y dislipidemia mixta.
Atorvastatin Farmacologia
Atorvastatina, un selectivo y competitivo de la HMG-CoA reductasa, se utiliza para reducir el colesterol y los triglicéridos en pacientes con hipercolesterolemia y dislipidemia mixta y en el tratamiento de homocigotos hipercolesterolemia familiar. Atorvastatina tiene una estructura única, larga vida media, y la selectividad hepática, que explica su mayor potencia de disminución de LDL en comparación con otros inhibidores de la HMG-CoA reductasa.
Atorvastatin Absorcion
La atorvastatina se absorbe rápidamente tras la administración oral. La biodisponibilidad absoluta de atorvastatina (droga madre) es de aproximadamente 14% y la disponibilidad sistémica de inhibidores de la HMG-CoA reductasa actividad inhibitoria es de aproximadamente 30%.
Atorvastatin Toxicidad
Rabdomiolisis, hemorragias oculares, y problemas hepáticos.
Atorvastatin Informacion de Pacientes
Lipitor is a HMG-CoA Reductase Inhibitor, also known as a statin. This class
of treatments for high cholesterol is fairly new, and appears to work by
blocking a liver enzyme which generates cholesterol. This medication appears
to be the most effective in this class of drugs at lowering unhealthy LDL
(low-density lipoprotein) cholesterol levels, in some cases up to 51%. It
can be virtually as effective as an angioplasty in treating stable coronary
artery disease. Currently, this drug is approved for use in patients with
high cholesterol (hypercholesterolemia) due to high LDL levels, hereditary
elevated fat levels (dysbetalipoproteinemia), familial high cholesterol,
and to increase HDL (high-density lipoprotein) levels in patients with high
cholesterol and those with both high cholesterol and high triglycerides (mixed
dyslipidemia). Other accepted uses include the treatment of stable coronary
artery diseas, preventing coronary heart disease, preventing clogged stents
(tubes) placed in coronary arteries after surgery, preventing bone loss in
type two diabetics, stabilizing lipid levels that have been altered by treatment
with protease inhibitors. This treatment should be considered a last resort.
The best way to lower cholesterol is through a program of healthy diet and
exercise, and these should be maintained during treatment with Lipitor.
of treatments for high cholesterol is fairly new, and appears to work by
blocking a liver enzyme which generates cholesterol. This medication appears
to be the most effective in this class of drugs at lowering unhealthy LDL
(low-density lipoprotein) cholesterol levels, in some cases up to 51%. It
can be virtually as effective as an angioplasty in treating stable coronary
artery disease. Currently, this drug is approved for use in patients with
high cholesterol (hypercholesterolemia) due to high LDL levels, hereditary
elevated fat levels (dysbetalipoproteinemia), familial high cholesterol,
and to increase HDL (high-density lipoprotein) levels in patients with high
cholesterol and those with both high cholesterol and high triglycerides (mixed
dyslipidemia). Other accepted uses include the treatment of stable coronary
artery diseas, preventing coronary heart disease, preventing clogged stents
(tubes) placed in coronary arteries after surgery, preventing bone loss in
type two diabetics, stabilizing lipid levels that have been altered by treatment
with protease inhibitors. This treatment should be considered a last resort.
The best way to lower cholesterol is through a program of healthy diet and
exercise, and these should be maintained during treatment with Lipitor.
Atorvastatin Organismos afectados
Humanos y otros mamíferos
