PharmacyCodes



Voriconazole en es it fr

Voriconazole Brand names, Voriconazole Analogs

Voriconazole Brand Names Mixture

  • No information avaliable

Voriconazole Chemical_Formula

C16H14F3N5O

Voriconazole RX_link

http://www.rxlist.com/cgi/generic/vfend.htm

Voriconazole fda sheet

Voriconazole FDA

Voriconazole msds (material safety sheet)

Voriconazole MSDS

Voriconazole Synthesis Reference

No information avaliable

Voriconazole Molecular Weight

349.311 g/mol

Voriconazole Melting Point

127 - 130 oC

Voriconazole H2O Solubility

Low

Voriconazole State

Solid

Voriconazole LogP

2.561

Voriconazole Dosage Forms

Tablet; Oral suspension; IV injection

Voriconazole Indication

For the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp.

Voriconazole Pharmacology

Voriconazole is a triazole antifungal agent indicated for use in the treatment of fungal infections including invasive aspergillosis, esophageal candidiasis, and serious fungal infections caused by Scedosporium apiospermum (asexual form of Pseudallescheria boydii) and Fusarium spp. including Fusarium solani. Fungal plasma membranes are similar to mammalian plasma membranes, differing in having the nonpolar sterol ergosterol, rather than cholesterol, as the principal sterol. Membrane sterols such as ergosterol provide structure, modulation of membrane fluidity, and possibly control of some physiologic events. Voriconazole effects the formation of the fungal plasma membrane by indirectly inhibiting the biosynthesis of ergosterol. This results in plasma membrane permeability changes and inhibition of growth.

Voriconazole Absorption

The oral bioavailability is estimated to be 96% (CV 13%).

Voriconazole side effects and Toxicity

The minimum lethal oral dose in mice and rats was 300 mg/kg (equivalent to 4 and 7 times the recommended maintenance dose (RMD), based on body surface area). At this dose, clinical signs observed in both mice and rats included salivation, mydriasis, titubation (loss of balance while moving), depressed behavior, prostration, partially closed eyes, and dyspnea. Other signs in mice were convulsions, corneal opacification and swollen abdomen.

Voriconazole Patient Information

Voriconazole Organisms Affected

Yeast and other fungi