Valrubicin
Valrubicin Brand names, Valrubicin Analogs
Valrubicin Brand Names Mixture
- No information avaliable
Valrubicin Chemical_Formula
C34H36F3NO13
Valrubicin RX_link
http://www.rxlist.com/cgi/generic2/rubicin.htm
Valrubicin fda sheet
Valrubicin msds (material safety sheet)
Valrubicin Synthesis Reference
No information avaliable
Valrubicin Molecular Weight
723.644 g/mol
Valrubicin Melting Point
116-117oC
Valrubicin H2O Solubility
insoluble
Valrubicin State
Solid
Valrubicin LogP
3.332
Valrubicin Dosage Forms
Liquid
Valrubicin Indication
Bladder cancer
Valrubicin Pharmacology
When 800 mg Valstar was administered intravesically to patients with carcinoma in situ, Valstar penetrated into the bladder wall. The mean total anthracycline concentration measured in bladder tissue exceeded the levels causing 90% cytoxicity to human bladder cells cultured in vitro. During the two-hour dose-retention period, the metabolism of Valstar to its major metabolites N-trifluoroacetyladriamycin and N-trifluoroacetyladriamycinol was neglible. After retention, the drug was almost completely excreted by voiding the instillate. Mean percent recovery of Valstar, N-trifluoroacetyladriamycin, and total anthracyclines in 14 urine samples from six patients was 98.6%, 0.4%, and 99.0% of the total administered drug, respectively. During the two-hour dose-retention period, only nanogram quantities of Valstar were absorbed into the plasma.
Valrubicin Absorption
No information avaliable
Valrubicin side effects and Toxicity
No information avaliable
Valrubicin Patient Information
Valrubicin Organisms Affected
Humans and other mammals
