Trifluridine en es it fr

Trifluridine Brand names, Trifluridine Analogs

Trifluridine Brand Names Mixture

  • No information avaliable

Trifluridine Chemical_Formula


Trifluridine RX_link

Trifluridine fda sheet

Trifluridine msds (material safety sheet)

Trifluridine Synthesis Reference

No information avaliable

Trifluridine Molecular Weight

296.2 g/mol

Trifluridine Melting Point

186-189 oC

Trifluridine H2O Solubility

1560 mg/L

Trifluridine State


Trifluridine LogP


Trifluridine Dosage Forms

Ophthalmic solution 1% (drops)

Trifluridine Indication

Ophthalmic solution for the treatment of primay keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus, types 1 and 2.

Trifluridine Pharmacology

Trifluridine is a fluorinated pyrimidine nucleoside with in vitro and in vivo activity against herpes simplex virus, types 1 and 2 and vacciniavirus. Some strains of adenovirus are also inhibited in vitro. Trifluridine is also effective in the treatment of epithelial keratitis that has not responded clinically to the topical administration of idoxuridine or when ocular toxicity or hypersensitivity to idoxuridine has occurred. In a smaller number of patients found to be resistant to topical vidarabine, trifluridine was also effective. Trifluridine interferes with DNA synthesis in cultured mammalian cells. However, its antiviral mechanism of action is not completely known.

Trifluridine Absorption

Systemic absorption of trifluridine following therapeutic dosing with trifluridine ophthalmic appears to be negligible.

Trifluridine side effects and Toxicity

Overdosage by ocular instillation is unlikely because any excess solution should be quickly expelled from the conjunctival sac. Acute overdosage by accidental oral ingestion has not occurred. However, should such ingestion occur, the 75 mg dosage of trifluridine in a 7.5 mL bottle of trifluridine is not likely to produce adverse effects. Single intravenous doses of 1.5 to 30 mg/kg/day in children and adults with neoplastic disease produce reversible bone marrow depression as the only potentially serious toxic effect and only after three to five courses of therapy. The acute oral LD50 in the mouse and rat was 4379 mg/kg or higher.

Trifluridine Patient Information

Trifluridine Organisms Affected

Human herpes virus