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Trandolapril Brand names, Trandolapril Analogs

Trandolapril Brand Names Mixture

  • No information avaliable

Trandolapril Chemical_Formula


Trandolapril RX_link

Trandolapril fda sheet

Trandolapril msds (material safety sheet)

Trandolapril MSDS

Trandolapril Synthesis Reference

No information avaliable

Trandolapril Molecular Weight

430.537 g/mol

Trandolapril Melting Point


Trandolapril H2O Solubility

No information avaliable

Trandolapril State


Trandolapril LogP


Trandolapril Dosage Forms

Capsule; Tablets (1 mg, 2 mg, or 4 mg of trandolapril for oral administration)

Trandolapril Indication

For the treatment of hypertension.

Trandolapril Pharmacology

Trandolapril is the ethyl ester prodrug of a nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, trandolaprilat. Trandolapril is deesterified to the diacid metabolite, trandolaprilat, which is approximately eight times more active as an inhibitor of ACE activity. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor, angiotensin II. Angiotensin II is a potent peripheral vasoconstrictor that also stimulates secretion of aldosterone by the adrenal cortex and provides negative feedback for renin secretion.

Trandolapril Absorption

Absolute bioavailability after oral administration of trandolapril is about 10% as trandolapril and 70% as trandolaprilat. Food slows absorption of trandolapril, but does not affect the area under the plasma concentration–time curve (AUC) or peak plasma concentration (Cmax) of trandolaprilat or Cmax of trandolapril.

Trandolapril side effects and Toxicity

No data are available with respect to overdosage in humans. The oral LD50 of trandolapril in mice was 4875 mg/Kg in males and 3990 mg/Kg in females. In rats, an oral dose of 5000 mg/Kg caused low mortality (1 male out of 5; 0 females). In dogs, an oral dose of 1000 mg/Kg did not cause mortality and abnormal clinical signs were not observed. In humans the most likely clinical manifestation would be symptoms attributable to severe hypotension.

Trandolapril Patient Information

Trandolapril Organisms Affected

Humans and other mammals