Ticlopidine
Ticlopidine Brand names, Ticlopidine Analogs
Ticlopidine Brand Names Mixture
- No information avaliable
Ticlopidine Chemical_Formula
C14H14ClNS
Ticlopidine RX_link
http://www.rxlist.com/cgi/generic/ticlop.htm
Ticlopidine fda sheet
Ticlopidine msds (material safety sheet)
Ticlopidine Synthesis Reference
No information avaliable
Ticlopidine Molecular Weight
263.786 g/mol
Ticlopidine Melting Point
No information avaliable
Ticlopidine H2O Solubility
Freely soluble
Ticlopidine State
Solid
Ticlopidine LogP
3.46
Ticlopidine Dosage Forms
Tablets (for oral administration, containing 250 mg of ticlopidine hydrochloride)
Ticlopidine Indication
Used to reduce the risk of thrombotic stroke (fatal or nonfatal) in patients who have experienced stroke precursors, and in patients who have had a completed thrombotic stroke.
Ticlopidine Pharmacology
Ticlopidine is a platelet aggregation inhibitor structurally and pharmacologically similar to clopidogrel. When taken orally, ticlopidine causes a time- and dose-dependent inhibition of both platelet aggregation and release of platelet granule constituents, as well as a prolongation of bleeding time. The intact drug has no significant in vitro activity at the concentrations attained in vivo; and, although analysis of urine and plasma indicates at least 20 metabolites, no metabolite which accounts for the activity of ticlopidine has been isolated.
Ticlopidine Absorption
Absorption is greater than 80%. Food increases absorption.
Ticlopidine side effects and Toxicity
Single oral doses of ticlopidine at 1600 mg/kg and 500 mg/kg were lethal to rats and mice, respectively. Symptoms of acute toxicity were GI hemorrhage, convulsions, hypothermia, dyspnea, loss of equilibrium and abnormal gait.
Ticlopidine Patient Information
Ticlopidine Organisms Affected
Humans and other mammals
