Sulfanilamide, N(sup 1)-2-pyridyl-
Brand names,
Sulfanilamide, N(sup 1)-2-pyridyl-
Analogs
Sulfanilamide, N(sup 1)-2-pyridyl-
Brand Names Mixture
- Foot Rot Boluses (Ethylenediamine Dihydroiodide + Sulfapyridine)
- Neutral Sulfa 50 (Sulfamethazine + Sulfapyridine + Sulfathiazole)
- Neutral Sulfa 7 (Sulfamethazine + Sulfapyridine + Sulfathiazole)
- Trisulfa G Liq (Sulfamethazine + Sulfapyridine + Sulfathiazole)
Sulfanilamide, N(sup 1)-2-pyridyl-
Chemical_Formula
C11H11N3O2S
Sulfanilamide, N(sup 1)-2-pyridyl-
RX_link
No information avaliable
Sulfanilamide, N(sup 1)-2-pyridyl-
fda sheet
Sulfanilamide, N(sup 1)-2-pyridyl-
msds (material safety sheet)
Sulfanilamide, N(sup 1)-2-pyridyl-
Synthesis Reference
No information avaliable
Sulfanilamide, N(sup 1)-2-pyridyl-
Molecular Weight
249.29 g/mol
Sulfanilamide, N(sup 1)-2-pyridyl-
Melting Point
192 oC
Sulfanilamide, N(sup 1)-2-pyridyl-
H2O Solubility
268 mg/L
Sulfanilamide, N(sup 1)-2-pyridyl-
State
Solid
Sulfanilamide, N(sup 1)-2-pyridyl-
LogP
2.384
Sulfanilamide, N(sup 1)-2-pyridyl-
Dosage Forms
Tablet
Sulfanilamide, N(sup 1)-2-pyridyl-
Indication
For the treatment of dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum
Sulfanilamide, N(sup 1)-2-pyridyl-
Pharmacology
Sulfapyridine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Sulfanilamide, N(sup 1)-2-pyridyl-
Absorption
approximately 60-80%
Sulfanilamide, N(sup 1)-2-pyridyl-
side effects and Toxicity
ORL-RAT 15800 mg/Kg
Sulfanilamide, N(sup 1)-2-pyridyl-
Patient Information
PATIENT INFORMATION
Follow the links
http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202536.html
http://www.drugs.com/cons/Sulfapyridine.html
Sulfanilamide, N(sup 1)-2-pyridyl-
Organisms Affected
Humans and other mammals