Succimer
Brand names,
Succimer
Analogs
Succimer
Brand Names Mixture
Succimer
Chemical_Formula
C4H6O4S2
Succimer
RX_link
http://www.rxlist.com/cgi/generic2/succimer.htm
Succimer
fda sheet
Succimer
msds (material safety sheet)
Succimer
Synthesis Reference
No information avaliable
Succimer
Molecular Weight
182.22 g/mol
Succimer
Melting Point
193 oC
Succimer
H2O Solubility
No information avaliable
Succimer
State
Solid
Succimer
LogP
0.048
Succimer
Dosage Forms
Capsules (opaque, for oral administration, containing beads coated with 100 mg of succimer)
Succimer
Indication
For the treatment of lead poisoning in pediatric patients with blood lead levels above 45 µg/dL. May also be used to treat mercury or arsenic poisoning.
Succimer
Pharmacology
Succimer is an orally active, heavy metal chelating agent. It forms water soluble chelates and, consequently, increases the urinary excretion of lead. Succimer is not to be used for prophylaxis of lead poisoning in a lead-containing environment. In addition, the use of succimer should always be accompanied by identification and removal of the source of the lead exposure.
Succimer
Absorption
Rapid but variable.
Succimer
side effects and Toxicity
Oral LD50 in mice is over 5011 mg/kg. Doses of 2300 mg/kg in the rat and 2400 mg/kg in the mouse produced ataxia, convulsions, labored respiration and frequently death. No case of overdosage has been reported in humans. Limited data indicate that succimer is dialyzable.
Succimer
Patient Information
Succimer
Organisms Affected
Humans and other mammals