Succimer
Succimer Brand names, Succimer Analogs
Succimer Brand Names Mixture
- No information avaliable
Succimer Chemical_Formula
C4H6O4S2
Succimer RX_link
http://www.rxlist.com/cgi/generic2/succimer.htm
Succimer fda sheet
Succimer msds (material safety sheet)
Succimer Synthesis Reference
No information avaliable
Succimer Molecular Weight
182.22 g/mol
Succimer Melting Point
193 oC
Succimer H2O Solubility
No information avaliable
Succimer State
Solid
Succimer LogP
0.048
Succimer Dosage Forms
Capsules (opaque, for oral administration, containing beads coated with 100 mg of succimer)
Succimer Indication
For the treatment of lead poisoning in pediatric patients with blood lead levels above 45 µg/dL. May also be used to treat mercury or arsenic poisoning.
Succimer Pharmacology
Succimer is an orally active, heavy metal chelating agent. It forms water soluble chelates and, consequently, increases the urinary excretion of lead. Succimer is not to be used for prophylaxis of lead poisoning in a lead-containing environment. In addition, the use of succimer should always be accompanied by identification and removal of the source of the lead exposure.
Succimer Absorption
Rapid but variable.
Succimer side effects and Toxicity
Oral LD50 in mice is over 5011 mg/kg. Doses of 2300 mg/kg in the rat and 2400 mg/kg in the mouse produced ataxia, convulsions, labored respiration and frequently death. No case of overdosage has been reported in humans. Limited data indicate that succimer is dialyzable.
Succimer Patient Information
Succimer Organisms Affected
Humans and other mammals
