Renagel
Renagel Brand names, Renagel Analogs
Renagel Brand Names Mixture
- No information avaliable
Renagel Chemical_Formula
C4H6O4S2
Renagel RX_link
http://www.rxlist.com/cgi/generic2/succimer.htm
Renagel fda sheet
Renagel msds (material safety sheet)
Renagel Synthesis Reference
No information avaliable
Renagel Molecular Weight
182.22 g/mol
Renagel Melting Point
193 oC
Renagel H2O Solubility
No information avaliable
Renagel State
Solid
Renagel LogP
0.048
Renagel Dosage Forms
Capsules (opaque, for oral administration, containing beads coated with 100 mg of succimer)
Renagel Indication
For the treatment of lead poisoning in pediatric patients with blood lead levels above 45 µg/dL. May also be used to treat mercury or arsenic poisoning.
Renagel Pharmacology
Succimer is an orally active, heavy metal chelating agent. It forms water soluble chelates and, consequently, increases the urinary excretion of lead. Succimer is not to be used for prophylaxis of lead poisoning in a lead-containing environment. In addition, the use of succimer should always be accompanied by identification and removal of the source of the lead exposure.
Renagel Absorption
Rapid but variable.
Renagel side effects and Toxicity
Oral LD50 in mice is over 5011 mg/kg. Doses of 2300 mg/kg in the rat and 2400 mg/kg in the mouse produced ataxia, convulsions, labored respiration and frequently death. No case of overdosage has been reported in humans. Limited data indicate that succimer is dialyzable.
Renagel Patient Information
Renagel Organisms Affected
Humans and other mammals
