Sotalol
Sotalol Brand names, Sotalol Analogs
Sotalol Brand Names Mixture
- Sans-Acne Solution (Alcohol Anhydrous + Erythromycin)
- Staticin Lot (Alcohol Anhydrous + Erythromycin + Laureth 4)
- T-Stat Lot (Alcohol Anhydrous + Erythromycin)
- T-Stat Pad-Lot (Alcohol Anhydrous + Erythromycin)
Sotalol Chemical_Formula
C12H20N2O3S
Sotalol RX_link
http://www.rxlist.com/cgi/generic/betapaceaf.htm
Sotalol fda sheet
Sotalol msds (material safety sheet)
Sotalol Synthesis Reference
No information avaliable
Sotalol Molecular Weight
272.365 g/mol
Sotalol Melting Point
206.5-207 oC
Sotalol H2O Solubility
Soluble (5510 mg/L)
Sotalol State
Solid
Sotalol LogP
2.382
Sotalol Dosage Forms
Tablets (white, capsule-shaped, for oral administration)
Sotalol Indication
For the maintenance of normal sinus rhythm [delay in time to recurrence of atrial fibrillation/atrial flutter (AFIB/AFL)] in patients with symptomatic AFIB/AFL who are currently in sinus rhythm. Also for the treatment of documented life-threatening ventricular arrhythmias.
Sotalol Pharmacology
Sotalol is an antiarrhythmic drug. It falls into the class of beta blockers (and class II antiarrhythmic agents) because of its primary action on the β-adrenergic receptors in the heart. In addition to its actions on the beta receptors in the heart, sotalol inhibits the inward potassium ion channels of the heart. In so doing, sotalol prolongs repolarization, therefore lengthening the QT interval and decreasing automaticity. It also slows atrioventricular (AV) nodal conduction. Because of these actions on the cardiac action potential, it is also considered a class III antiarrhythmic agent. The beta-blocking effect of sotalol is non-cardioselective, half maximal at about 80mg/day and maximal at doses between 320 and 640 mg/day. Sotalol does not have partial agonist or membrane stabilizing activity. Although significant beta-blockade occurs at oral doses as low as 25 mg, significant Class Ieffects are seen only at daily doses of 160 mg and above.
Sotalol Absorption
In healthy subjects, the oral bioavailability of sotalol is 90-100%. Absorption is reduced by approximately 20% compared to fasting when administered with a standard meal.
Sotalol side effects and Toxicity
The most common signs to be expected are bradycardia, congestive heart failure, hypotension, bronchospasm and hypoglycemia. In cases of massive intentional overdosage (2-16 grams) of sotalol the following clinical findings were seen: hypotension, bradycardia, cardiac asystole, prolongation of QT interval, Torsade de Pointes, ventricular tachy-cardia, and premature ventricular complexes.
Sotalol Patient Information
Sotalol Organisms Affected
Humans and other mammals
