Normix
Normix Brand names, Normix Analogs
Normix Brand Names Mixture
- Sans-Acne Solution (Alcohol Anhydrous + Erythromycin)
- Staticin Lot (Alcohol Anhydrous + Erythromycin + Laureth 4)
- T-Stat Lot (Alcohol Anhydrous + Erythromycin)
- T-Stat Pad-Lot (Alcohol Anhydrous + Erythromycin)
Normix Chemical_Formula
C12H20N2O3S
Normix RX_link
http://www.rxlist.com/cgi/generic/betapaceaf.htm
Normix fda sheet
Normix msds (material safety sheet)
Normix Synthesis Reference
No information avaliable
Normix Molecular Weight
272.365 g/mol
Normix Melting Point
206.5-207 oC
Normix H2O Solubility
Soluble (5510 mg/L)
Normix State
Solid
Normix LogP
2.382
Normix Dosage Forms
Tablets (white, capsule-shaped, for oral administration)
Normix Indication
For the maintenance of normal sinus rhythm [delay in time to recurrence of atrial fibrillation/atrial flutter (AFIB/AFL)] in patients with symptomatic AFIB/AFL who are currently in sinus rhythm. Also for the treatment of documented life-threatening ventricular arrhythmias.
Normix Pharmacology
Sotalol is an antiarrhythmic drug. It falls into the class of beta blockers (and class II antiarrhythmic agents) because of its primary action on the β-adrenergic receptors in the heart. In addition to its actions on the beta receptors in the heart, sotalol inhibits the inward potassium ion channels of the heart. In so doing, sotalol prolongs repolarization, therefore lengthening the QT interval and decreasing automaticity. It also slows atrioventricular (AV) nodal conduction. Because of these actions on the cardiac action potential, it is also considered a class III antiarrhythmic agent. The beta-blocking effect of sotalol is non-cardioselective, half maximal at about 80mg/day and maximal at doses between 320 and 640 mg/day. Sotalol does not have partial agonist or membrane stabilizing activity. Although significant beta-blockade occurs at oral doses as low as 25 mg, significant Class Ieffects are seen only at daily doses of 160 mg and above.
Normix Absorption
In healthy subjects, the oral bioavailability of sotalol is 90-100%. Absorption is reduced by approximately 20% compared to fasting when administered with a standard meal.
Normix side effects and Toxicity
The most common signs to be expected are bradycardia, congestive heart failure, hypotension, bronchospasm and hypoglycemia. In cases of massive intentional overdosage (2-16 grams) of sotalol the following clinical findings were seen: hypotension, bradycardia, cardiac asystole, prolongation of QT interval, Torsade de Pointes, ventricular tachy-cardia, and premature ventricular complexes.
Normix Patient Information
Normix Organisms Affected
Humans and other mammals
