Soriatane
Soriatane Brand names, Soriatane Analogs
Soriatane Brand Names Mixture
- No information avaliable
Soriatane Chemical_Formula
C21H26O3
Soriatane RX_link
http://www.rxlist.com/cgi/generic3/acitretin.htm
Soriatane fda sheet
Soriatane msds (material safety sheet)
Soriatane Synthesis Reference
No information avaliable
Soriatane Molecular Weight
326.429 g/mol
Soriatane Melting Point
228-230 oC
Soriatane H2O Solubility
0.0729 mg/L
Soriatane State
Solid
Soriatane LogP
4.84
Soriatane Dosage Forms
10 mg and 25 mg gelatin capsules for oral administration
Soriatane Indication
For the treatment of severe psoriasis in adults.
Soriatane Pharmacology
Acitretin is a retinoid. Retinoids have a structure similar to vitamin A and are involved in the normal growth of skin cells. Acitretin works by inhibiting the excessive cell growth and keratinisation (process by which skin cells become thickened due to the deposition of a protein within them) seen in psoriasis. It therefore reduces the thickening of the skin, plaque formation and scaling.
Soriatane Absorption
Oral absorption of acitretin is optimal when given with food, and is linear and proportional with increasing doses from 25 to 100 mg. Approximately 72% (range 47% to 109%) of the administered dose was absorbed after a single 50 mg dose of acitretin was given to 12 healthy subjects.
Soriatane side effects and Toxicity
Oral, rat: LD50 = >4000 mg/kg. Symptoms of overdose include headache and vertigo.
Soriatane Patient Information
Soriatane Organisms Affected
Humans and other mammals
