Acetretin
Acetretin Brand names, Acetretin Analogs
Acetretin Brand Names Mixture
- No information avaliable
Acetretin Chemical_Formula
C21H26O3
Acetretin RX_link
http://www.rxlist.com/cgi/generic3/acitretin.htm
Acetretin fda sheet
Acetretin msds (material safety sheet)
Acetretin Synthesis Reference
No information avaliable
Acetretin Molecular Weight
326.429 g/mol
Acetretin Melting Point
228-230 oC
Acetretin H2O Solubility
0.0729 mg/L
Acetretin State
Solid
Acetretin LogP
4.84
Acetretin Dosage Forms
10 mg and 25 mg gelatin capsules for oral administration
Acetretin Indication
For the treatment of severe psoriasis in adults.
Acetretin Pharmacology
Acitretin is a retinoid. Retinoids have a structure similar to vitamin A and are involved in the normal growth of skin cells. Acitretin works by inhibiting the excessive cell growth and keratinisation (process by which skin cells become thickened due to the deposition of a protein within them) seen in psoriasis. It therefore reduces the thickening of the skin, plaque formation and scaling.
Acetretin Absorption
Oral absorption of acitretin is optimal when given with food, and is linear and proportional with increasing doses from 25 to 100 mg. Approximately 72% (range 47% to 109%) of the administered dose was absorbed after a single 50 mg dose of acitretin was given to 12 healthy subjects.
Acetretin side effects and Toxicity
Oral, rat: LD50 = >4000 mg/kg. Symptoms of overdose include headache and vertigo.
Acetretin Patient Information
Acetretin Organisms Affected
Humans and other mammals
