Reductil
Reductil Brand names, Reductil Analogs
Reductil Brand Names Mixture
- No information avaliable
Reductil Chemical_Formula
C17H26ClN
Reductil RX_link
http://www.rxlist.com/cgi/generic/sibutramine.htm
Reductil fda sheet
Reductil msds (material safety sheet)
Reductil Synthesis Reference
No information avaliable
Reductil Molecular Weight
279.848 g/mol
Reductil Melting Point
191-192 oC
Reductil H2O Solubility
2.9 mg/mL (in pH 5.2 water)
Reductil State
Solid
Reductil LogP
5.906
Reductil Dosage Forms
Capsules
Reductil Indication
For the treatment of obesity.
Reductil Pharmacology
Sibutramine is an orally administered agent for the treatment of obesity. Sibutramine exerts its pharmacological actions predominantly via its secondary (M1) and primary (M2) amine metabolites. The parent compound, sibutramine, is a potent inhibitor of serotonin and norepinephrine reuptake in vivo, but not in vitro. However, metabolites M1 and M2 inhibit the reuptake of these neurotransmitters both in vitro and in vivo. In human brain tissue, M1 and M2 also inhibit dopamine reuptake in vitro, but with ~3-fold lower potency than for the reuptake inhibition of serotonin or norepinephrine. Sibutramine, M1 and M2 exhibit no evidence of anticholinergic or antihistaminergic actions. In addition, receptor binding profiles show that sibutramine, M1 and M2 have low affinity for serotonin (5-HT1, 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C), norepinephrine (b, b1, b3, a1 and a2), dopamine (D1 and D2), benzodiazepine, and glutamate (NMDA) receptors. These compounds also lack monoamine oxidase inhibitory activity in vitro and in vivo.
Reductil Absorption
Rapid absorption following oral administration. Absolute bioavailability is not known, but at least 77% of a single oral dose of sibutramine is absorbed.
Reductil side effects and Toxicity
Side effects include dry mouth, anorexia, insomnia, constipation and headache.
Reductil Patient Information
APRD00456_PI.txt
Reductil Organisms Affected
Humans and other mammals
