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Meridia Brand names, Meridia Analogs

Meridia Brand Names Mixture

  • No information avaliable

Meridia Chemical_Formula


Meridia RX_link

Meridia fda sheet

Meridia FDA

Meridia msds (material safety sheet)

Meridia Synthesis Reference

No information avaliable

Meridia Molecular Weight

279.848 g/mol

Meridia Melting Point

191-192 oC

Meridia H2O Solubility

2.9 mg/mL (in pH 5.2 water)

Meridia State


Meridia LogP


Meridia Dosage Forms


Meridia Indication

For the treatment of obesity.

Meridia Pharmacology

Sibutramine is an orally administered agent for the treatment of obesity. Sibutramine exerts its pharmacological actions predominantly via its secondary (M1) and primary (M2) amine metabolites. The parent compound, sibutramine, is a potent inhibitor of serotonin and norepinephrine reuptake in vivo, but not in vitro. However, metabolites M1 and M2 inhibit the reuptake of these neurotransmitters both in vitro and in vivo. In human brain tissue, M1 and M2 also inhibit dopamine reuptake in vitro, but with ~3-fold lower potency than for the reuptake inhibition of serotonin or norepinephrine. Sibutramine, M1 and M2 exhibit no evidence of anticholinergic or antihistaminergic actions. In addition, receptor binding profiles show that sibutramine, M1 and M2 have low affinity for serotonin (5-HT1, 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C), norepinephrine (b, b1, b3, a1 and a2), dopamine (D1 and D2), benzodiazepine, and glutamate (NMDA) receptors. These compounds also lack monoamine oxidase inhibitory activity in vitro and in vivo.

Meridia Absorption

Rapid absorption following oral administration. Absolute bioavailability is not known, but at least 77% of a single oral dose of sibutramine is absorbed.

Meridia side effects and Toxicity

Side effects include dry mouth, anorexia, insomnia, constipation and headache.

Meridia Patient Information


Meridia Organisms Affected

Humans and other mammals