PharmacyCodes



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Quixalin Brand names, Quixalin Analogs

Quixalin Brand Names Mixture

  • No information avaliable

Quixalin Chemical_Formula

C58H105N16Na5O28S5

Quixalin RX_link

http://www.rxlist.com/cgi/generic2/colistimethate.htm

Quixalin fda sheet

Quixalin msds (material safety sheet)

Quixalin MSDS

Quixalin Synthesis Reference

No information avaliable

Quixalin Molecular Weight

1749.82 g/mol

Quixalin Melting Point

No information avaliable

Quixalin H2O Solubility

Appreciable

Quixalin State

Solid

Quixalin LogP

No information avaliable

Quixalin Dosage Forms

Vials containing colistimethate sodium or pentasodium colistinmethanesulfonate (150 mg colistin base activity) for injection.

Quixalin Indication

For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa.

Quixalin Pharmacology

Colistimethate is a polymyxin antibiotic agent. Originally, colistimethate sodium was thought to be less toxic than polymyxin B; however, if the drugs are administered at comparable doses, their toxicities may be similar. Polymyxins are cationic polypeptides that disrupt the bacterial cell membrane through a detergentlike mechanism. With the development of less toxic agents, such as extended-spectrum penicillins and cephalosporins, parenteral polymyxin use was largely abandoned, except for the treatment of multidrug-resistant pulmonary infections in patients with cystic fibrosis. More recently, however, the emergence of multidrug-resistant gram-negative bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, and the lack of new antimicrobial agents have led to the revived use of the polymyxins.

Quixalin Absorption

Very poor absorption from gastrointestinal tract.

Quixalin side effects and Toxicity

Oral LD50 in rats is 5450 mg/kg. Overdosage with colistimethate can cause neuromuscular blockade characterized by paresthesia, lethargy, confusion, dizziness, ataxia, nystagmus, disorders of speech and apnea. Respiratory muscle paralysis may lead to apnea, respiratory arrest and death.

Quixalin Patient Information

Quixalin Organisms Affected

Gram-negative bacilli