PharmacyCodes



Clofuzid en es it fr

Clofuzid Brand names, Clofuzid Analogs

Clofuzid Brand Names Mixture

  • No information avaliable

Clofuzid Chemical_Formula

C58H105N16Na5O28S5

Clofuzid RX_link

http://www.rxlist.com/cgi/generic2/colistimethate.htm

Clofuzid fda sheet

Clofuzid msds (material safety sheet)

Clofuzid MSDS

Clofuzid Synthesis Reference

No information avaliable

Clofuzid Molecular Weight

1749.82 g/mol

Clofuzid Melting Point

No information avaliable

Clofuzid H2O Solubility

Appreciable

Clofuzid State

Solid

Clofuzid LogP

No information avaliable

Clofuzid Dosage Forms

Vials containing colistimethate sodium or pentasodium colistinmethanesulfonate (150 mg colistin base activity) for injection.

Clofuzid Indication

For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa.

Clofuzid Pharmacology

Colistimethate is a polymyxin antibiotic agent. Originally, colistimethate sodium was thought to be less toxic than polymyxin B; however, if the drugs are administered at comparable doses, their toxicities may be similar. Polymyxins are cationic polypeptides that disrupt the bacterial cell membrane through a detergentlike mechanism. With the development of less toxic agents, such as extended-spectrum penicillins and cephalosporins, parenteral polymyxin use was largely abandoned, except for the treatment of multidrug-resistant pulmonary infections in patients with cystic fibrosis. More recently, however, the emergence of multidrug-resistant gram-negative bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, and the lack of new antimicrobial agents have led to the revived use of the polymyxins.

Clofuzid Absorption

Very poor absorption from gastrointestinal tract.

Clofuzid side effects and Toxicity

Oral LD50 in rats is 5450 mg/kg. Overdosage with colistimethate can cause neuromuscular blockade characterized by paresthesia, lethargy, confusion, dizziness, ataxia, nystagmus, disorders of speech and apnea. Respiratory muscle paralysis may lead to apnea, respiratory arrest and death.

Clofuzid Patient Information

Clofuzid Organisms Affected

Gram-negative bacilli