Podophyllotoxin
Podophyllotoxin Brand names, Podophyllotoxin Analogs
Podophyllotoxin Brand Names Mixture
- No information avaliable
Podophyllotoxin Chemical_Formula
C8H17NO2
Podophyllotoxin RX_link
http://www.rxlist.com/cgi/generic4/lyrica.htm
Podophyllotoxin fda sheet
Podophyllotoxin msds (material safety sheet)
Podophyllotoxin Synthesis Reference
No information avaliable
Podophyllotoxin Molecular Weight
159.226 g/mol
Podophyllotoxin Melting Point
No information avaliable
Podophyllotoxin H2O Solubility
No information avaliable
Podophyllotoxin State
Solid
Podophyllotoxin LogP
0.844
Podophyllotoxin Dosage Forms
Capsule
Podophyllotoxin Indication
For management of neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia.
Podophyllotoxin Pharmacology
Pregabalin is a new anticonvulsant drug indicated as an add on therapy for partial onset seizures and for certain types of neuropathic pain. It was designed as a more potent successor to a related drug, gabapentin. Pregabalin binds to the alpha2-delta subunit of the voltage-gated calcium channel in the central nervous system. While pregabalin is a structural derivative of the inhibitory neurotransmitter gamma- aminobutyric acid (GABA), it does not bind directly to GABAA, GABAB, or benzodiazepine receptors, does not augment GABAA responses in cultured neurons, does not alter rat brain GABA concentration or have acute effects on GABA uptake or degradation. However, in cultured neurons prolonged application of pregabalin increases the density of GABA transporter protein and increases the rate of functional GABA transport. Pregabalin does not block sodium channels, is not active at opiate receptors, and does not alter cyclooxygenase enzyme activity. It is inactive at serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline reuptake.
Podophyllotoxin Absorption
Well absorbed after oral administration.
Podophyllotoxin side effects and Toxicity
No information avaliable
Podophyllotoxin Patient Information
No information avaliable
Podophyllotoxin Organisms Affected
Humans and other mammals
