Podophyllinic acid lactone
Podophyllinic acid lactone Brand names, Podophyllinic acid lactone Analogs
Podophyllinic acid lactone Brand Names Mixture
- No information avaliable
Podophyllinic acid lactone Chemical_Formula
C8H17NO2
Podophyllinic acid lactone RX_link
http://www.rxlist.com/cgi/generic4/lyrica.htm
Podophyllinic acid lactone fda sheet
Podophyllinic acid lactone msds (material safety sheet)
Podophyllinic acid lactone Synthesis Reference
No information avaliable
Podophyllinic acid lactone Molecular Weight
159.226 g/mol
Podophyllinic acid lactone Melting Point
No information avaliable
Podophyllinic acid lactone H2O Solubility
No information avaliable
Podophyllinic acid lactone State
Solid
Podophyllinic acid lactone LogP
0.844
Podophyllinic acid lactone Dosage Forms
Capsule
Podophyllinic acid lactone Indication
For management of neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia.
Podophyllinic acid lactone Pharmacology
Pregabalin is a new anticonvulsant drug indicated as an add on therapy for partial onset seizures and for certain types of neuropathic pain. It was designed as a more potent successor to a related drug, gabapentin. Pregabalin binds to the alpha2-delta subunit of the voltage-gated calcium channel in the central nervous system. While pregabalin is a structural derivative of the inhibitory neurotransmitter gamma- aminobutyric acid (GABA), it does not bind directly to GABAA, GABAB, or benzodiazepine receptors, does not augment GABAA responses in cultured neurons, does not alter rat brain GABA concentration or have acute effects on GABA uptake or degradation. However, in cultured neurons prolonged application of pregabalin increases the density of GABA transporter protein and increases the rate of functional GABA transport. Pregabalin does not block sodium channels, is not active at opiate receptors, and does not alter cyclooxygenase enzyme activity. It is inactive at serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline reuptake.
Podophyllinic acid lactone Absorption
Well absorbed after oral administration.
Podophyllinic acid lactone side effects and Toxicity
No information avaliable
Podophyllinic acid lactone Patient Information
No information avaliable
Podophyllinic acid lactone Organisms Affected
Humans and other mammals
