Perphenazine and Amitriptyline Hcl

Perphenazine and Amitriptyline Hcl Brand names, Perphenazine and Amitriptyline Hcl Analogs

Perphenazine and Amitriptyline Hcl Brand Names Mixture

Apo Peram Tab 2-25 (Amitriptyline Hydrochloride + Perphenazine)
Apo Peram Tab 3-15 (Amitriptyline Hydrochloride + Perphenazine)
Elavil Plus Tab (Amitriptyline Hydrochloride + Perphenazine)
Etrafon 2 10 (Amitriptyline Hydrochloride + Perphenazine)
Etrafon a Tab (Amitriptyline Hydrochloride + Perphenazine)
Etrafon D Tab (Amitriptyline Hydrochloride + Perphenazine)
Etrafon F Tab (Amitriptyline Hydrochloride + Perphenazine)
Pms-Levazine 2/25 Tab (Amitriptyline Hydrochloride + Perphenazine)
Pms-Levazine 3/15 Tab (Amitriptyline Hydrochloride + Perphenazine)
Pms-Levazine 4/25 Tab (Amitriptyline Hydrochloride + Perphenazine)
Proavil Tab (Amitriptyline Hydrochloride + Perphenazine)
Triavil Tab (Amitriptyline Hydrochloride + Perphenazine)

Perphenazine and Amitriptyline Hcl Chemical_Formula

C₂₁H₂₆ClN₃OS

Perphenazine and Amitriptyline Hcl RX_link

http://www.rxlist.com/cgi/generic3/perphenazine.htm

Perphenazine and Amitriptyline Hcl fda sheet

Perphenazine_and_Amitriptyline_Hcl FDA

Perphenazine and Amitriptyline Hcl msds (material safety sheet)

Perphenazine_and_Amitriptyline_Hcl MSDS

Perphenazine and Amitriptyline Hcl Synthesis Reference

Cusic, U.S. pat. 2860138

Perphenazine and Amitriptyline Hcl Molecular Weight

403.969 g/mol

Perphenazine and Amitriptyline Hcl Melting Point

97 ^oC

Perphenazine and Amitriptyline Hcl H₂O Solubility

28.3 mg/L

Perphenazine and Amitriptyline Hcl State

Solid

Perphenazine and Amitriptyline Hcl LogP

4.176

Perphenazine and Amitriptyline Hcl Dosage Forms

Liquid; Solution; Syrup; Tablet (2, 4, 8, or 16 mg)

Perphenazine and Amitriptyline Hcl Indication

For use in the management of the manifestations of psychotic disorders and for the control of severe nausea and vomiting in adults.

Perphenazine and Amitriptyline Hcl Pharmacology

Perphenazine is a piperazinyl phenothiazine, acts on the central nervous system, and has a greater behavioral potency than other phenothiazine derivatives whose side chains do not contain a piperazine moiety. It is a member of a class of drugs called phenothiazines, which are dopamine D1/D2 receptor antagonists. Perphenazine is 10 to 15 times as potent as chlorpromazine; that means perphenazine is a highly potent antipsychotic. In equivalent doses it has approximately the same frequency and severity of early and late extrapypramidal side-effects compared to Haloperidol.

Perphenazine and Amitriptyline Hcl Absorption

Absolute bioavailability is 40% following oral administration.

Perphenazine and Amitriptyline Hcl side effects and Toxicity

Symptoms of overdose include stupor or coma, and children may have convulsive seizures. Signs of arousal may not occur for 48 hours. Oral LD₅₀=318 mg/kg (rat); IPR LD₅₀=64 mg/kg (mouse)

Perphenazine and Amitriptyline Hcl Patient Information

This information is intended to aid in the safe and effective use of this medication. It is not a disclosure of all possible adverse or intended effects.

Given the likelihood that a substantial proportion of patients exposed chronically to neuroleptics will develop tardive dyskinesia, it is advised that all patients in whom chronic use is contemplated be given, if possible, full information about this risk. The decision to inform patients and/or their guardians must obviously take into account the clinical circumstances and the competency of the patient to understand the information provided.

Perphenazine and Amitriptyline Hcl Organisms Affected

Humans and other mammals