Apo-Perphenazine
Brand names,
Apo-Perphenazine
Analogs
Apo-Perphenazine
Brand Names Mixture
- Apo Peram Tab 2-25 (Amitriptyline Hydrochloride + Perphenazine)
- Apo Peram Tab 3-15 (Amitriptyline Hydrochloride + Perphenazine)
- Elavil Plus Tab (Amitriptyline Hydrochloride + Perphenazine)
- Etrafon 2 10 (Amitriptyline Hydrochloride + Perphenazine)
- Etrafon a Tab (Amitriptyline Hydrochloride + Perphenazine)
- Etrafon D Tab (Amitriptyline Hydrochloride + Perphenazine)
- Etrafon F Tab (Amitriptyline Hydrochloride + Perphenazine)
- Pms-Levazine 2/25 Tab (Amitriptyline Hydrochloride + Perphenazine)
- Pms-Levazine 3/15 Tab (Amitriptyline Hydrochloride + Perphenazine)
- Pms-Levazine 4/25 Tab (Amitriptyline Hydrochloride + Perphenazine)
- Proavil Tab (Amitriptyline Hydrochloride + Perphenazine)
- Triavil Tab (Amitriptyline Hydrochloride + Perphenazine)
Apo-Perphenazine
Chemical_Formula
C21H26ClN3OS
Apo-Perphenazine
RX_link
http://www.rxlist.com/cgi/generic3/perphenazine.htm
Apo-Perphenazine
fda sheet
Apo-Perphenazine
msds (material safety sheet)
Apo-Perphenazine
Synthesis Reference
Cusic, U.S. pat. 2860138
Apo-Perphenazine
Molecular Weight
403.969 g/mol
Apo-Perphenazine
Melting Point
97 oC
Apo-Perphenazine
H2O Solubility
28.3 mg/L
Apo-Perphenazine
State
Solid
Apo-Perphenazine
LogP
4.176
Apo-Perphenazine
Dosage Forms
Liquid; Solution; Syrup; Tablet (2, 4, 8, or 16 mg)
Apo-Perphenazine
Indication
For use in the management of the manifestations of psychotic disorders and for the control of severe nausea and vomiting in adults.
Apo-Perphenazine
Pharmacology
Perphenazine is a piperazinyl phenothiazine, acts on the central nervous system, and has a greater behavioral potency than other phenothiazine derivatives whose side chains do not contain a piperazine moiety. It is a member of a class of drugs called phenothiazines, which are dopamine D1/D2 receptor antagonists. Perphenazine is 10 to 15 times as potent as chlorpromazine; that means perphenazine is a highly potent antipsychotic. In equivalent doses it has approximately the same frequency and severity of early and late extrapypramidal side-effects compared to Haloperidol.
Apo-Perphenazine
Absorption
Absolute bioavailability is 40% following oral administration.
Apo-Perphenazine
side effects and Toxicity
Symptoms of overdose include stupor or coma, and children may have convulsive seizures. Signs of arousal may not occur for 48 hours. Oral LD50=318 mg/kg (rat); IPR LD50=64 mg/kg (mouse)
Apo-Perphenazine
Patient Information
This information is intended to aid in the safe and effective use of this medication. It is not a disclosure of
all possible adverse or intended effects.
Given the likelihood that a substantial proportion of patients exposed chronically to neuroleptics will develop
tardive dyskinesia, it is advised that all patients in whom chronic use is contemplated be given, if possible, full
information about this risk. The decision to inform patients and/or their guardians must obviously take into account
the clinical circumstances and the competency of the patient to understand the information provided.
Apo-Perphenazine
Organisms Affected
Humans and other mammals