Paludrine
Paludrine Brand names, Paludrine Analogs
Paludrine Brand Names Mixture
- No information avaliable
Paludrine Chemical_Formula
C11H16ClN5
Paludrine RX_link
No information avaliable
Paludrine fda sheet
Paludrine msds (material safety sheet)
Paludrine Synthesis Reference
No information avaliable
Paludrine Molecular Weight
253.731 g/mol
Paludrine Melting Point
129 oC
Paludrine H2O Solubility
156 mg/L
Paludrine State
Solid
Paludrine LogP
2.558
Paludrine Dosage Forms
Tablet
Paludrine Indication
For the causal prevention and suppression of malaria caused by susceptible strains of P. falciparum and other species of Plasmodium found in some geographical areas of the world.
Paludrine Pharmacology
Proguanil is a biguanide derivative that is converted to an active metabolite called cycloguanil pamoate. It exerts its antimalarial action by inhibiting parasitic dihydrofolate reductase enzyme. It has causal prophylactic and suppressive activity against P. falciparum and cures the acute infection. It is also effective in suppressing the clinical attacks of vivax malaria. However it is slower compared to 4-aminoquinolines.
Paludrine Absorption
Rapidly and well absorbed in humans following oral doses ranging from 50 to 500 mg.
Paludrine side effects and Toxicity
No information avaliable
Paludrine Patient Information
No information avaliable
Paludrine Organisms Affected
Plasmodium
