Chloroguanide
Chloroguanide Brand names, Chloroguanide Analogs
Chloroguanide Brand Names Mixture
- No information avaliable
Chloroguanide Chemical_Formula
C11H16ClN5
Chloroguanide RX_link
No information avaliable
Chloroguanide fda sheet
Chloroguanide msds (material safety sheet)
Chloroguanide Synthesis Reference
No information avaliable
Chloroguanide Molecular Weight
253.731 g/mol
Chloroguanide Melting Point
129 oC
Chloroguanide H2O Solubility
156 mg/L
Chloroguanide State
Solid
Chloroguanide LogP
2.558
Chloroguanide Dosage Forms
Tablet
Chloroguanide Indication
For the causal prevention and suppression of malaria caused by susceptible strains of P. falciparum and other species of Plasmodium found in some geographical areas of the world.
Chloroguanide Pharmacology
Proguanil is a biguanide derivative that is converted to an active metabolite called cycloguanil pamoate. It exerts its antimalarial action by inhibiting parasitic dihydrofolate reductase enzyme. It has causal prophylactic and suppressive activity against P. falciparum and cures the acute infection. It is also effective in suppressing the clinical attacks of vivax malaria. However it is slower compared to 4-aminoquinolines.
Chloroguanide Absorption
Rapidly and well absorbed in humans following oral doses ranging from 50 to 500 mg.
Chloroguanide side effects and Toxicity
No information avaliable
Chloroguanide Patient Information
No information avaliable
Chloroguanide Organisms Affected
Plasmodium
