Orgalutran
Orgalutran Brand names, Orgalutran Analogs
Orgalutran Brand Names Mixture
- No information avaliable
Orgalutran Chemical_Formula
C55H75N17O13
Orgalutran RX_link
http://www.rxlist.com/cgi/generic2/gonadorelin.htm
Orgalutran fda sheet
Orgalutran msds (material safety sheet)
Orgalutran Synthesis Reference
No information avaliable
Orgalutran Molecular Weight
1182.29 g/mol
Orgalutran Melting Point
No information avaliable
Orgalutran H2O Solubility
1 mg/mL
Orgalutran State
Liquid
Orgalutran LogP
-4.634
Orgalutran Dosage Forms
Liquid; Powder for solution; Solution for infusion pump
Orgalutran Indication
For evaluating the functional capacity and response of the gonadotropes of the anterior pituitary also for evaluating residual gonadotropic function of the pituitary following removal of a pituitary tumor by surgery and/or irradiation.
Orgalutran Pharmacology
Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens. The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use
Orgalutran Absorption
Rapidly absorbed when injected
Orgalutran side effects and Toxicity
LD50>3000 mg/kg (rat, oral)
Orgalutran Patient Information
Orgalutran Organisms Affected
Humans and other mammals
