Antagon
Antagon Brand names, Antagon Analogs
Antagon Brand Names Mixture
- No information avaliable
Antagon Chemical_Formula
C55H75N17O13
Antagon RX_link
http://www.rxlist.com/cgi/generic2/gonadorelin.htm
Antagon fda sheet
Antagon msds (material safety sheet)
Antagon Synthesis Reference
No information avaliable
Antagon Molecular Weight
1182.29 g/mol
Antagon Melting Point
No information avaliable
Antagon H2O Solubility
1 mg/mL
Antagon State
Liquid
Antagon LogP
-4.634
Antagon Dosage Forms
Liquid; Powder for solution; Solution for infusion pump
Antagon Indication
For evaluating the functional capacity and response of the gonadotropes of the anterior pituitary also for evaluating residual gonadotropic function of the pituitary following removal of a pituitary tumor by surgery and/or irradiation.
Antagon Pharmacology
Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens. The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use
Antagon Absorption
Rapidly absorbed when injected
Antagon side effects and Toxicity
LD50>3000 mg/kg (rat, oral)
Antagon Patient Information
Antagon Organisms Affected
Humans and other mammals
