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Norglycin Brand names, Norglycin Analogs

Norglycin Brand Names Mixture

  • No information avaliable

Norglycin Chemical_Formula


Norglycin RX_link

Norglycin fda sheet

Norglycin FDA

Norglycin msds (material safety sheet)

Norglycin MSDS

Norglycin Synthesis Reference

No information avaliable

Norglycin Molecular Weight

390.513 g/mol

Norglycin Melting Point

No information avaliable

Norglycin H2O Solubility

Insoluble at 25°C

Norglycin State


Norglycin LogP


Norglycin Dosage Forms

Solution for injection (supplied in 20 mL multi-use vials in four strengths, containing 1 mg/mL, 2.5 mg/mL, 5 mg/mL or 10 mg/mL of treprostinil)

Norglycin Indication

For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.

Norglycin Pharmacology

Pulmonary arterial hypertension (PAH) is a disease in which blood pressure is abnormally high in the arteries between the heart and lungs. PAH is characterized by symptoms of shortness of breath during physical exertion. The condition can ultimately lead to heart failure. Treprostinil is a potent oral antiplatelet agent. The major pharmacologic actions of treprostinil are direct vasodilation of pulmonary and systemic arterial vascular beds and inhibition of platelet aggregation. In animals, the vasodilatory effects reduce right and left ventricular afterload and increase cardiac output and stroke volume. Other studies have shown that treprostinil causes a dose-related negative inotropic and lusitropic effect. No major effects on cardiac conduction have been observed.

Norglycin Absorption

Relatively rapid and complete after subcutaneous infusion, with an absolute bioavailability approximately 100%. In patients with mild (n=4) or moderate (n=5) hepatic insufficiency and portopulmonary hypertension following a subcutaneous dose of 10 ng per kg of body weight per min for 150 mins the AUC 0-∞ was increased 3-fold and 5-fold respectively.

Norglycin side effects and Toxicity

Symptoms of overdose are extensions of its dose-limiting pharmacologic effects and include flushing, headache, hypotension, nausea, vomiting, and diarrhea. Most events were self-limiting and resolved with reduction or withholding of treprostinil.

Norglycin Patient Information

Norglycin Organisms Affected

Humans and other mammals