Natalizumab
Natalizumab Brand names, Natalizumab Analogs
Natalizumab Brand Names Mixture
- No information avaliable
Natalizumab Chemical_Formula
No information avaliable
Natalizumab RX_link
http://www.rxlist.com/cgi/generic3/tysabri.htm
Natalizumab fda sheet
Natalizumab msds (material safety sheet)
Natalizumab Synthesis Reference
Sequence listed in Leger OJ, Yednock TA, Tanner L, Horner HC, Hines DK, Keen S, Saldanha J, Jones ST, Fritz LC, Bendig MM. Humanization of a mouse antibody against human alpha-4 integrin: a potential therapeutic for the treatment of multiple sclerosis. Hum Antibodies. 1997;8(1):3-16
Natalizumab Molecular Weight
No information avaliable
Natalizumab Melting Point
61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000).
Natalizumab H2O Solubility
No information avaliable
Natalizumab State
Liquid
Natalizumab LogP
No information avaliable
Natalizumab Dosage Forms
Solution (IV Infusion)
Natalizumab Indication
For treatment of multiple sclerosis
Natalizumab Pharmacology
In multiple sclerosis, lesions are believed to occur when activated inflammatory cells, including T-lymphocytes, cross the blood-brain barrier (BBB). Leukocyte migration across the BBB involves interaction between adhesion molecules on inflammatory cells, and their counter-receptors present on endothelial cells of the vessel wall. The clinical effect of natalizumab in multiple sclerosis may be a secondary result of its blockade of the molecular interaction of a 4b 1-integrin expressed by inflammatory cells with VCAM-1 on vascular endothelial cells, and with CS-1 and/or osteopontin expressed by parenchymal cells in the brain.
Natalizumab Absorption
No information avaliable
Natalizumab side effects and Toxicity
No information avaliable
Natalizumab Patient Information
BIOD00083.html
Natalizumab Organisms Affected
Humans and other mammals
