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Natalizumab Brand names, Natalizumab Analogs

Natalizumab Brand Names Mixture

  • No information avaliable

Natalizumab Chemical_Formula

No information avaliable

Natalizumab RX_link

Natalizumab fda sheet

Natalizumab msds (material safety sheet)

Natalizumab Synthesis Reference

Sequence listed in Leger OJ, Yednock TA, Tanner L, Horner HC, Hines DK, Keen S, Saldanha J, Jones ST, Fritz LC, Bendig MM. Humanization of a mouse antibody against human alpha-4 integrin: a potential therapeutic for the treatment of multiple sclerosis. Hum Antibodies. 1997;8(1):3-16

Natalizumab Molecular Weight

No information avaliable

Natalizumab Melting Point

61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000).

Natalizumab H2O Solubility

No information avaliable

Natalizumab State


Natalizumab LogP

No information avaliable

Natalizumab Dosage Forms

Solution (IV Infusion)

Natalizumab Indication

For treatment of multiple sclerosis

Natalizumab Pharmacology

In multiple sclerosis, lesions are believed to occur when activated inflammatory cells, including T-lymphocytes, cross the blood-brain barrier (BBB). Leukocyte migration across the BBB involves interaction between adhesion molecules on inflammatory cells, and their counter-receptors present on endothelial cells of the vessel wall. The clinical effect of natalizumab in multiple sclerosis may be a secondary result of its blockade of the molecular interaction of a 4b 1-integrin expressed by inflammatory cells with VCAM-1 on vascular endothelial cells, and with CS-1 and/or osteopontin expressed by parenchymal cells in the brain.

Natalizumab Absorption

No information avaliable

Natalizumab side effects and Toxicity

No information avaliable

Natalizumab Patient Information


Natalizumab Organisms Affected

Humans and other mammals