Nafarelin
Nafarelin Brand names, Nafarelin Analogs
Nafarelin Brand Names Mixture
- No information avaliable
Nafarelin Chemical_Formula
C66H83N17O13
Nafarelin RX_link
http://www.rxlist.com/cgi/generic2/nafarelin.htm
Nafarelin fda sheet
Nafarelin msds (material safety sheet)
Nafarelin Synthesis Reference
No information avaliable
Nafarelin Molecular Weight
1321.6344 g/mol
Nafarelin Melting Point
No information avaliable
Nafarelin H2O Solubility
No information avaliable
Nafarelin State
Solid
Nafarelin LogP
No information avaliable
Nafarelin Dosage Forms
Liquid; Metered-dose (aerosol)
Nafarelin Indication
For treatment of gonadotropin-dependent precocious puberty in children of both sexes and for the treatment of endometriosis.
Nafarelin Pharmacology
Nafarelin is a potent agonistic analog of gonadotropin-releasing hormone (GnRH). At the onset of administration, nafarelin stimulates the release of the pituitary gonadotropins, LH and FSH, resulting in a temporary increase of gonadal steroidogenesis. Repeated dosing abolishes the stimulatory effect on the pituitary gland. Twice daily administration leads to decreased secretion of gonadal steroids by about 4 weeks; consequently, tissues and functions that depend on gonadal steroids for their maintenance become quiescent. After nafarelin therapy is discontinued, pituitary and ovarian function normalize and estradiol serum concentrations increase to pretreatment levels. Recurrences of endometriosis are frequent after cessation of any hormonal therapy and after surgery that leaves the ovaries and/or uterus intact.
Nafarelin Absorption
Rapidly absorbed into the systemic circulation after intranasal administration. Bioavailability from a 400 µg dose averaged 2.8% (range 1.2 to 5.6%). Not absorbed after oral administration.
Nafarelin side effects and Toxicity
In experimental animals, a single subcutaneous administration of up to 60 times the recommended human dose (on a µg/kg basis, not adjusted for bioavailability) had no adverse effects. At present, there is no clinical evidence of adverse effects following overdosage of GnRH analogs.
Nafarelin Patient Information
Nafarelin Organisms Affected
Humans and other mammals
